The Siberian Scientific Medical Journal
 
 
№ 4 / 2017 / 5-10

STUDY OF ANTIFIBROTIC ACTIVITY OF MODIFIED AND NATIVE HYALURONIDASE AT PULMONARY FIBROSIS

Author Affiliations

Abstract

This study of the antifibrotic activity of poloxamer-modified and native hyaluronidase was conducted using the model of partial reversible pulmonary fibrosis caused by one-time administration of bleomycine. The preparations were administered in the intranasal preventive and therapeutic modes. It has been established that modified hyaluronidase when used in the therapeutic mode has more pronounced antifibrotic action in comparison to native enzyme. When administered in the preventive mode, modified hyaluronidase prevents the development of pulmonary fibrosis.

Key words

poloxamer, pulmonary fibrosis, hyaluronidase
References
About Authors (Correspondence):

Madonov P.G. – doctor of medical sciences, professor, head of the chair for pharmacology, clinical pharmacology and evidentiary medicine, e-mail:madonov@scpb.ru

Full Text

Received: 08/09/2017