OF THE USE OF PROTEIN TISSUE-SPECIFIC MARKERS IN THE ESTIMATION OF SEVERITY OF COMMUNITY-ACQUIRED PNEUMONIA

Author: Voevoda M.I.¹, Ragino Yu.I.², Nikolaev K.Yu.³, Kharlamova O.S.⁴, Stakhneva E.M.⁵, Kashtanova E.V.⁶, Polonskaya Ya.V.⁷, Ivanoshchuk D.E.⁸, Kruchinina M.V.⁹, Kruchinin V.N.¹⁰

Author Affiliations

¹Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1; Federal Research Center for Fundamental and Translational Medicine 630117, Novosibirsk, Timakov str., 2; The Federal Research Center Institute of Cytology and Genetics of SB RAS 630090, Novosibirsk, Academician Lavrentiev av., 10; Novosibirsk State University 630090, Novosibirsk, Pirogov str., 2

²Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1

³Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1; Novosibirsk State University 630090, Novosibirsk, Pirogov str., 2

⁴Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1

⁵Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1

⁶Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1

⁷Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1

⁸Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1; The Federal Research Center Institute of Cytology and Genetics of SB RAS 630090, Novosibirsk, Academician Lavrentiev av., 10

⁹Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics of SB RAS 630089, Novosibirsk, Boris Bogatkov str., 175/1; Novosibirsk State Medical University 630091, Novosibirsk, Krasny av., 52

¹⁰Rzhanov Institute of Semiconductor Physics of SB RAS 630090, Novosibirsk, Academician Lavrentiev av., 13

Abstract

The purpose of the study was to assess the associations of proteins of pulmonary surfactants A (SP-A) and D (SP-D) with the severity of community-acquired pneumonia. Material and methods. A survey of 188 patients diagnosed with community-acquired pneumonia (CAP). The average age of the examined patients was 54.3 ± 16.5 years (M ± SD). In 102 patients (54.3 %) severe CAP was verified. All patients underwent clinical, functional, diagnostic and laboratory studies. Results and discussion. It was determined that SP-A and SP-D content was significantly higher in patients with severe CAP compared to patients with a mild course of this disease. The direct association of severe CAP with an elevated SP-AP level, directly associated with an increase in the concentration of C-reactive protein in the blood and erythrocyte sedimentation rate, have been confirmed in early studies. Using partial correlation analysis, it was established that the severe course of CAP is directly related to SP-A (r = 0.221; p = 0.003) and SP-D content (r = 0.262; p < 0.001) regardless of age, smoking, and body weight. Thus, direct associations of SP-A and SP-D with a severe course of CAP reflect the high pathogenetic significance of these protective factors in infectious lung damage.

Key words

pulmonary surfactant proteins A and D, community-acquired pneumonia, partial correlation analysis, blood serum, severe pneumonia

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About Authors (Correspondence):

Kruchinina M.V., e-mail: kruchmargo@yandex.ru

Full Text

snmzh_4-2019_voevoda_93-98.pdf

Received: 02/09/2019

Accepted: 02/09/2019