EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA

Author: Arbeneva N.S.¹, Chekhovа T.A.², Bratko V.I.³, Obukhovа O.O.⁴, Gorbenko O.M.⁵, Shvayuk A.P.⁶, Poveshchenko O.V.⁷, Trunov А.N.⁸, Chernykh V.V.⁹

Author Affiliations

Abstract

Purpose: to study the clinical and laboratory efficacy of the platelet autoplasma use in the complex treatment of endogenous uveitis associated with systemic diseases accompanied by macular edema. Material and methods. The study included 46 people (72 eyes) with endogenous uveitis and macular edema. The diagnosis was made on the basis of the ophthalmological examination, including visometry, tonometry, biomicroscopy, ophthalmoscopy, perimetry, B-scan, optical coherence tomography of the macular zone, photoregistration of the anterior, posterior segment of the eye. The examination was carried out on the 1st and 10th day of treatment. The main group consisted of 22 people (36 eyes) who underwent anti-inflammatory therapy and the introduction of platelet plasma in the region of the pterygopalatine fossa. The control group consisted of 24 people (36 eyes) receiving only anti-inflammatory therapy (diprospan 0.5 para-equatorially №1, dexazone 4 mg intravenously №5, intravenous lasix 2.0 ml №5, electrophoresis with prednisolone № 7). All patients underwent the definition of IL-4, IL-6, IL-8, IL-17 in tear fluid before the study and on the 10th day. Results. The significant increase in the concentrations of pro-inflammatory cytokines (IL-17A and IL-8) and IL-4 and IL-6 involved in the development of autoimmune response and chronic inflammation was found in the patients with endogenous uveitis and macular edema. The use in the treatment of endogenous uveitis with macular edema of platelet autoplasma leads to more pronounced improvement of clinico-ophthalmological parameters (improvement in visual acuity, retinal photosensitivity, and retinal thickness reduction) relating to the comparison group. A decrease in the activity of the inflammatory process was noted in the main group after treatment, which is manifested by a significant decrease in the concentrations of IL-17A, IL-8, IL-4, IL-6, relating to the data obtained in the comparison group. The proposed scheme of complex treatment allows reducing the frequency of relapses of the pathological process.

Key words

endogenous uveitis, macular edema, cytokines, platelet autoplasma

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About Authors (Correspondence):

Trunov A.N., e-mail: trunov1963@yandex ru

Full Text

snmzh_5-2019_arbeneva_i_dr.pdf

Received: 30/10/2019

Accepted: 30/10/2019