The Siberian Scientific Medical Journal
№ 2 / 2020 / 40-46
DOI 10.15372/SSMJ20200205

Composition based on aluminum oxide and polydimethylsiloxane – matrix for enhancing drug targeting

Author Affiliations


Methodological approaches developed at Research Institute of Clinical and Experimental Lymphology for a number of years allow formulating the importance of embedding active pharmaceutical ingredients (API) in the structure of porous carriers (sorbents). The composition of the carrier and API is an enteral system for prolonged dosing of pharmacological agents, which allows providing a specific pharmacological effect and safety of use. The pores of the media (sorbents) act as containers for API. This is especially important for rapidly absorbed drugs, which include, for example, lithium preparations that are used in narrow concentration limits due to their side effects. At the moment, an innovative technology for creating new medicines with an improved combination of efficiency and safety (pharmacological upgrade) has been developed and implemented. The essence of the technology is to create a composition of aluminum oxide and polydimethylsiloxane (matrix) and an active pharmacological ingredient (API). A study of two drugs based on matrix / lithium citrate and matrix / melatonin showed continued specific pharmacological activity of API, better pharmacokinetics, and better safety parameters. The matrix of aluminum oxide and polydimethylsiloxane provides an upgrade of the pharmacological properties of drugs for the dosed and safe delivery of API to the zone of their therapeutic effect.

Key words

lithium compositions, aluminum oxide, polydimethylsiloxane, pharmacological upgrade
About Authors (Correspondence):

Rachkovskaya L.N., e-mai:

Full Text

Received: 29/04/2020
Accepted: 29/04/2020