DOI 10.15372/SSMJ20200412
Features of HIV infection in adults
Author Affiliations1Penza State University 440026 Penza, Krasnaya str., 40
2Penza State University 440026 Penza, Krasnaya str., 40
3Penza State University 440026 Penza, Krasnaya str., 40
4Penza State University 440026 Penza, Krasnaya str., 40
5Penza State University 440026 Penza, Krasnaya str., 40
Abstract
Human immunodeficiency virus (HIV) infection remains a major medical problem due to its high prevalence and mortality. In order to study and identify clinical manifestations, frequency of their occurrence, as well as epidemiological features of this disease in the Penza region, we have analyzed 150 case histories. According to the results of the research, HIV infection is more common in men whose average age is 35.7 ± 9.1 years; in 69 % of cases-these are unemployed people; the average duration of the disease (by the date of registration at the dispensary) – 4.2 ± 4.1 years; unprotected sex is the leading factor of infection (35 %); there is a decrease in the share of infection by parenteral route with the use of drugs (32 %); in the structure of clinical manifestations, bronchopulmonary pathology (58 %) and chronic viral hepatitis C (60 %) prevails; diagnosed opportunistic infections were more often candidiasis of the oral cavity and esophagus (23 %), pneumocystic pneumonia (8 %) and Kaposi’s sarcoma (2 %). The etiological structure of purulent meningitis and meningoencephalitis is dominated by Staphylococcus aureus (25 %). The main etiological factor in the development of serous meningitis and meningoencephalitis are more often HSV DNA type 1, type 2 (12 %) and Enterovirus RNA (11 %).
Key words
ReferencesHIV infection and AIDS. Clinical recommendations. Ed. V.V. Pokrovsky. 4th ed. Moscow: GEOTAR-Media, 2019. 160 р. [In Russian].
2. Global AIDS monitoring 2019: indicators for monitoring the 2016 United Nations Political Declaration on HIV and AIDS. Geneva: UNAIDS, 2018. 203 p. doi: 10.18356/8175a524-en.
3. Reference of the Federal information and methodological center for AIDS prevention and control of the Federal state budgetary INSTITUTION Central research Institute of Rospotrebnadzor "HIV infection in the Russian Federation in 2018". [In Russian]. Available at: http://aids-centr.perm.ru/images/4/hiv_in_russia/hiv_in_rf_30.06.2018.pdf
4. Belyakov N.A., Rassokhin V.V., Stepanova E.V., Leonova O.N., Boeva E.V. HIV infection: an algorithm for forming a detailed clinical diagnosis. VICH-infektsiya i immunosupressii = HIV infection and immunosuppressions. 2018; 10 (1): 7-24. [In Russian].
5. Rumbwere Dube B.N., Marshall T.P., Ryan R.P., Omonijo M. Predictors of human immunodeficiency virus (HIV) infection in primary care among adults living in developed countries: a systematic review. Syst. Rev. 2018; 7 (1): 82. doi:10.1186/s13643-018-0744-3
6. "On HIV surveillance and the results of the implementation of the priority National project in the field of health (PPP) under the section "Prevention of HIV infection, hepatitis B and C, detection and treatment of HIV patients" in the Penza region for 6 months of 2019". Certificate of Rospotrebnadzor in the Penza region. [In Russian]. Available at: https://www.rospotrebnadzor.ru/about/info/news_region/news_details_region.php?ELEMENT_ID=12925.
7. Melnikov V.L., Rybalkin S.B., Aftayeva L.N., Mitrofanova N.N. Clinical and epidemiological features of HIV infection depending on the level of CD4 cells. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskiye nauki = University news. Volga region. Medical sciences. 2016; (3): 115-121. [In Russian]. doi: 10.21685/2072-3032-2016-3-13
8. Ameen M. Cutaneous markers of HIV infection and progression. Curr. HIV Res. 2010; 8 (6): 450‐455. doi: 10.2174/157016210793499349
About Authors (Correspondence):
Aftaeva L.N., e-mail: l.aftaeva@mail.ru
Full Text
Received: 26/08/2020
Accepted: 26/08/2020
