The Siberian Scientific Medical Journal
 
 
№ 3 / 2014 / 24-30

Polymorphism of MYOC gene in Western Siberian patients with primary open angle glaucoma

Author Affiliations

Abstract

AIM: to estimate the possible association between rs12035719 (–1000C/G), rs2075648 (–83g/a), rs2234926 (Arg76Lys) and rs2032555 (IVS2(+35G/A) polymorphisms of the MYOC gene and primary open angle glaucoma development in Western Siberian patients of European Origin. Materials and methods: 251 unrelated patients with primary open angle glaucoma and 303 unrelated healthy people were genotyped. RESULTS. It has been shown that rs12035719 (–1000C/G), rs2075648 (–83g/a), rs2234926 (Arg76Lys) polymorphisms of the MYOC gene do not affect a likelihood of the primary open angle glaucoma development. Carriage of the heterozygous genotype for the rs2032555 of the MYOC gene correlates with an increased risk of primary open angle glaucoma. The rs2075648 and rs2234926 polymorphisms are in the complete linkage disequilibrium in the cohorts.

Key words

MYOC gene, genetic predisposition, myocilin, multifactorial diseases, single nucleotide polymorphism, primary open angle glaucoma
References
About Authors (Correspondence):

Ivanoshchuk D.E. – junior researcher of the laboratory of the human molecular genetics, junior researcher of the laboratory of the molecular genetics therapeutic diseases, e-mail: dinara2084@mail.ru

Bychkov I.Yu. – ophthalmologist, e-mail: sci@mntk.nsk.ru

Mikhailova S.V. – candidate of biology sciences, researcher of the laboratory of the human molecular genetics, e-mail: mikhail@bionet.nsc.ru

Konovalova N.A. – doctor of medical sciences, professor, head of ophthalmologist upgrade qualifications and professional retraining chair, e-mail: doctork@bk.ru

Eremina A.V. – ophthalmologist, e-mail: sci@mntk.nsk.ru

Ponomareva M.N. – doctor of medical sciences, deputy director of medical services, e-mail: veteran-krgn@yandex.ru

Konovalova O.S. – candidate of medical sciences, head of the Tymen branch, e-mail: tumen_mntk@mail.ru

Voevoda M.I. – doctor of medical sciences, professor, head of the laboratory of the human molecular genetics, corresponding member of RAMS, director, e-mail: voevoda@ya.ru

Romashchenko A.G. – candidate of biology sciences, head of the interinstitute sector of molecular paleogenetics,
e-mail: romasch@bionet.nsc.ru

Full Text

Received: 09/02/2015