The Siberian Scientific Medical Journal
 
 
№ 4 / 2012 / 59-65

The role of Fas and FasL in immune-mediated mechanisms of development of slow progressing autoimmune diabetes mellitus at adults (LADA)

Author Affiliations

Abstract

The data on the pathogenesis of autoimmune problems of diabetes and its variants – LADA (latent autoimmune diabetes in adults) have been presented. It is established that one of the possible mechanisms of long-term preservation of endogenous insulin secretion in LADA is the activation of Fas / FasL apoptotic immune cells. Since Th2-cells are resistant to this mechanism, apoptosis, one can assume a more active elimination of autoaggressive Th1-lymphocytes from the circulation, less pronounced cell-mediated destruction b-cells and more «benign» course of insulitis at LADA patients.

Key words

Fas, FasL,, LADA, sFasL, autoimmune diabetes
References
About Authors (Correspondence):

Saprina T.V. – candidate of medical sciences, assistant of the chair for endocrinology and diabetology, e-mail: tvsaprina@sibmail.com

Prokhorenko T.S.postgraduate student of the chair pathological physiology, e-mail: tatjana_sp@sibmail.com

Lazarenko F.E.postgraduate student of the chair for endocrinology and diabetology, e-mail: feliksi@yandex.ru

Zima A.P.doctor of medical sciences, professor of the chair for fundamental principals of clinical medicine, e-mail: zima.a@mail.ru

Vasileva O.A. – candidate of medical sciences, assistant of the chair for fundamental principals of clinical medicine

Ryazantseva N.V. – doctor of medical sciences, head of the chair for fundamental principals of clinical medicine

Vorozhtsova I.N. – doctor of medical sciences, professor, head of the chair for endocrinology and diabetology, e-mail: abv@mail.tomsknet.ru

Full Text

Received: 09/02/2015