Peculiarities of decorin expression in heterotopic endometrium at two forms of genital endometriosis

To study the expression of dermatan sulfate proteoglycan decorin in two forms of genital endometriosis. Material and methods: 49 samples of surgical specimens of 14 patients with ovarial endometriosis and 3 women with adenomyosis; immunohistochemical two-step streptavidin-biotin method. The statistically significant more pronounced expression of dermatan sulfate proteoglycan decorin in the cellular elements of cytogenic stroma was demonstrated compared with samples of adenomyosis (p < 0.0001), and samples of endometrial cysts in women using combined oral contraceptives for 6 months before surgery. No significant differences in the expression of decorin in the endometrioid fibrous stroma of two forms of genital endometriosis were found.

1. Adamyan L.V., Andreeva E.N. Role of contemporary hormone-modulated therapy of multipurpose treatment of genital endometriosis // Problemy reproduktsii. 2011. (6). 66–77. (In Russian)
2. Kunin I.S., Boboev M.M., Kutsenko O.S. et al. Molecular markers of the prostate adenocarcinoma metastasis // Oncourologiya. 2012. (4). 44–48. (In Russian)
3. Berto A.G., Sampaio L.O., Franco C.R. et al. A comparative analysis of structure and spatial distribution of decorin in human leiomyoma and normal myometrium // Biochim. Biophys. Acta. 2003. 1619. 98–112.
4. Bondza P.K., Maheux R., Akoum A. Insights into endometriosis-associated endometrial dysfunctions: A review // Front. Biosci. 2009. 1. 415–428.
5. Iozzo R.V., Sanderson R.D. Proteoglycans in cancer biology, tumor microenvironment and angiogenesis // J. Cell. Mol. Med. 2011. 15. (5). 1013–1031.
6. Nash M.A., Deavers M.T., Freedman R.S. The expression of decorin in human ovarian tumors // Clin. Cancer Res. 2002. 8. (6). 1754–1760.
7. Neill T., Schaefer L., Iozzo R.V. Decorin: a guardian from the matrix // Am. J. Pathol. 2012. 181. (2). 380–387.
8. Suhovskih A.V., Mostovich L.A., Kunin I.S. et al. Proteoglycan expression in normal human prostate tissue and prostate cancer // ISRN Oncol. 2013. 2013. ID 680136.
9. Tsara M.E., Theocharis A.D., Theocharis D.A. Compositional and structural alterations of proteoglycans in human rectum carcinoma with special reference to versican and decorin // Anticancer Res. 2002. 22. (5). 2893–2898.
10. Wu I.-C., Wu D.-C., Huang C.-C. et al. Plasma decorin predicts the presence of esophageal squamous cell carcinoma // Int. J. Cancer. 2010. 127. 2138–2146.

Marinkin I.O. - doctor of medical sciences, professor, head of the chair for obstetrics and gynecology, rector
Aidagulova S.V. - doctor of biological sciences, professor, head of the laboratory for cellular biology and fundamental basis of reproduction, e-mail: a_sv@ngs.ru
Timofeeva Yu.S. - 6-year student of the chair for general medicine
Arkhipov S.A. - doctor of biological sciences, head of the laboratory for cytology and cell cultures
Kuleshov V.M. - doctor of medical sciences, professor of the chair for obstetrics and gynecology
Avdiyuk G.A. - candidate of medical sciences, professor assistant of the chair for obstetrics and gynecology
Kucherenko S.G. - candidate of medical sciences, associate professor of the chair for obstetrics and gynecology
Piven L.A. - candidate of medical sciences, associate professor of the chair for obstetrics and gynecology