The Siberian Scientific Medical Journal
 
 
№ 2 / 2014 / 29-33

Ultrastructural study of endometrial receptivity in pregravid treatment conditions at recurrent miscarriage

Author Affiliations

Abstract

OBJECTIVE: To study the dynamics of ultrastructural changes of endometrial epithelial cells at the result of pregravid treatment of the recurrent miscarriage. MATERIAL AND METHODS: 63 samples of endometrial biopsies of women in reproductive age with a luteal phase unsufficiency. Light and electron microscopy. RESULTS AND DISCUSSION: It has been revealed that pregravid cyclic hormone therapy (1 mg of 17?-estradiol and 20 mg of dydrogesterone) in comparisson with monotherapy by 20 mg of dydrogesterone during 3 months induced the intracellular regeneration and the implementation of the secretory phenotype of endometrial epithelial cells corresponding to the receptivity status with an "implantation open window".

Key words

hormonal therapy, recurrent pregnancy loss, endometrial receptivity, ultrastructure
References
About Authors (Correspondence):

Marinkin I.O. - doctor of medical sciences, professor, head of the chair for obstetrics and gynecology, rector
Nepomnyashchikh D.L. - doctor of medical sciences, professor, head of the laboratory for clinical morphology, deputy director on scientific work
Kuleshov V.M. - doctor of medical sciences, professor of the chair for obstetrics and gynecology
Ilizarova N.A. - doctor of medical sciences, associate professor of the chair for obstetrics and gynecology
Semchenko T.O. - post graduate student of the chair for obstetrics and gynecology
Aidagulova S.V. - doctor of biological sciences, professor, head of the laboratory for cellular biology and fundamental basis of reproduction, e-mail: a_sv@ngs.ru
 

Full Text

Received: 09/02/2015