Ultrastructural study of endometrial receptivity in pregravid treatment conditions at recurrent miscarriage
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
2Institute of Clinical and Experimental Lymphology of SB RAMS 630117, Novosibirsk, Timakov str., 2
3Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
41 Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
51 Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
6Novosibirsk State Medical University of Minzdrav of Russia 630091 , Novosibirsk, Krasny av., 52
Abstract
OBJECTIVE: To study the dynamics of ultrastructural changes of endometrial epithelial cells at the result of pregravid treatment of the recurrent miscarriage. MATERIAL AND METHODS: 63 samples of endometrial biopsies of women in reproductive age with a luteal phase unsufficiency. Light and electron microscopy. RESULTS AND DISCUSSION: It has been revealed that pregravid cyclic hormone therapy (1 mg of 17?-estradiol and 20 mg of dydrogesterone) in comparisson with monotherapy by 20 mg of dydrogesterone during 3 months induced the intracellular regeneration and the implementation of the secretory phenotype of endometrial epithelial cells corresponding to the receptivity status with an "implantation open window".
Key words
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About Authors (Correspondence):
Marinkin I.O. - doctor of medical sciences, professor, head of the chair for obstetrics and gynecology, rector
Nepomnyashchikh D.L. - doctor of medical sciences, professor, head of the laboratory for clinical morphology, deputy director on scientific work
Kuleshov V.M. - doctor of medical sciences, professor of the chair for obstetrics and gynecology
Ilizarova N.A. - doctor of medical sciences, associate professor of the chair for obstetrics and gynecology
Semchenko T.O. - post graduate student of the chair for obstetrics and gynecology
Aidagulova S.V. - doctor of biological sciences, professor, head of the laboratory for cellular biology and fundamental basis of reproduction, e-mail: a_sv@ngs.ru
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