Metabolic imprinting in fetal alcoholic intoxication

Fetal alcohol intoxication effect on offspring biochemical blood and pancreas parameters at different terms of postnatal period (15, 30 and 60 days) has been investigated. Dynamics differences in biochemical parameters of the offspring tissue were found: glucose and glycosamine contents changed in all studied terms; triglycerides level restored to 30 days, glycoproteins and glucuronic acid levels – to 60 days; plasmic insulin, glucagon levels, amylase activity and pancreas protein and non-protein sulfhydryl groups content at the early terms corresponded to the control group but changed considerably on a 60 day of a postnatal period. The data obtained suggest that prenatal alcohol intoxication has a significant impact on the pancreas and blood metabolic parameters not only in the early postnatal period but also renders the inoculation effect when achieving the reproductive period of ontogenesis.

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Vysokogorskiy V.Ye. – professor, doctor of medical sciences, professor of the chair of biochemistry, е-mail: vve-bio@mail.ru

Kurch N.M. – candidate of biological sciences, assistant professor of the chair of biochemistry, е-mail: nkurch@mail.ru