Clinical and morphological aspects of application of hyaluronic acid nanostructured biomaterial at corneal burns
Author Affiliations1The S. Fyodorov Eye Microsurgery Federal State Institution Orenburg Branch, 460047, Orenburg, Salmishskaya str., 17
2Orenburg State Medical Academy, 460000, Orenburg, Sovetskaya str., 6
3The S. Fyodorov Eye Microsurgery Federal State Institution Orenburg Branch, 460047, Orenburg, Salmishskaya str., 17
4The S. Fyodorov Eye Microsurgery Federal State Institution Orenburg Branch, 460047, Orenburg, Salmishskaya str., 17
Abstract
The aim of the study was to investigate the course of alkaline and acid corneal burns at bioplastic material based on hyaluronic acid usage. The study was performed on 36 rabbits (72 eyes) in 2 series: in the first series alkaline burn was formed (18 rabbits), and in the second one – the acid burn of the cornea (18 rabbits). At that the application of «Hyamatrix» was conducted in the experimental group and the eye gel «Solkoseryl» – in the control group. “Hyamatrix” is a biomaterial derived from a starting hyaluronic acid hydrogel exposed to ultraviolet irradiation. The application of biomaterial has created the conditions for the epithelialization acceleration and also helped to reduce the course of exudative phase of inflammation, a more rapid transition to the final proliferative phase and reduction of the rehabilitation terms.
Key words
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About Authors (Correspondence):
Kanyukov V.N. – honored doctor of the RF, professor, director
Stadnikov A.A. – honored worker of science of the RF, professor, head of department
Trubina O.M. – candidate of medical sciences, associate professor, deputy director for scientific work
Yakhina O.M. – ophthalmologist
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