The Siberian Scientific Medical Journal
№ 3 / 2014 / 37-41

Clinical and morphological aspects of application of hyaluronic acid nanostructured biomaterial at corneal burns

Author Affiliations


The aim of the study was to investigate the course of alkaline and acid corneal burns at bioplastic material based on hyaluronic acid usage. The study was performed on 36 rabbits (72 eyes) in 2 series: in the first series alkaline burn was formed (18 rabbits), and in the second one – the acid burn of the cornea (18 rabbits). At that the application of «Hyamatrix» was conducted in the experimental group and the eye gel «Solkoseryl» – in the control group. “Hyamatrix” is a biomaterial derived from a starting hyaluronic acid hydrogel exposed to ultraviolet irradiation. The application of biomaterial has created the conditions for the epithelialization acceleration and also helped to reduce the course of exudative phase of inflammation, a more rapid transition to the final proliferative phase and reduction of the rehabilitation terms.

Key words

aseptic inflammation, biomaterial «Hyamatrix», hyaluronic acid, corneal burn, experiment, regeneration
About Authors (Correspondence):

Kanyukov V.N. – honored doctor of the RF, professor, director

Stadnikov A.A. – honored worker of science of the RF, professor, head of department

Trubina O.M. – candidate of medical sciences, associate professor, deputy director for scientific work

Yakhina O.M. – ophthalmologist

Full Text

Received: 10/02/2015