The use of fibroblast growth factor for mesenchymal stromal cell generation in hematological malignancies

The impact of basic fibroblast growth factor (FGF-b) on the proliferative activity of mesenchymal stromal cells (MSCs) generated from bone marrow of patients with hematological malignancies (n = 16) was investigated. It has been shown that in patients with acute leukemia and lymphoma MSC generation in the presence of FGF-b accompanied by a decrease of cultivation until confluence, increase in cell yield and the number of cycling MSCs. At the same time, the MSCs of patients with aplastic anemia are characterized by low sensitivity to the FGF-b stimulatory effects. These data indicate the feasibility of FGF-b using to optimize MSC-based protocols in the treatment of some hematological malignancies.

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Chernykh E.R. – corresponding member of RAMS, doctor of medical sciences, professor, e-mail: ct_lab@mail.ru