The effectiveness of the first and repeated induction courses of patients with de novo acute myeloid leukemia

Complete remission is the main condition to improve survival of patients with acute myeloid leukemia (AML). The results of first induction of chemotherapy (CT) «7 + 3» of 93 patients aged from 17 to 76 years with de novo AML were next: in 59.1 % – complete remission (CR), in 33.1 % – no response and in 7.5 % – early death. The variant of response depended on the age and character of cytogenetic aberrations. The worst results were in AML patients with monosomal karyotype. The CT according to the scheme «7 + 3» or with the cytarabine introduction by single dose ≥ 1 g/m² at mono-regime or in combination with anthracyclines antibiotics has been used as the second induction course. The effectiveness of the second induction therapy was very low. CR was reached only in 11,5 % patients with intermediate karyotype regardless of the intensity of the CT. The conclusion that the intensity and composition of second CT has to be dependent on karyotype has been made.

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Abdulkadyrov K.M. – doctor of medical sciences, professor, the honored worker of sciences of the Russian Federation, head of hematology clinic, e-mail: rniiht@mail.ru