Pathological changes and expression of vascular endothelial growth factor in the placenta in inherited thrombophilia
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasni av., 52
2Municipal Clinical Hospital № 1 630047, Novosibirsk, Zalesski str., 6
3Novosibirsk State Medical University of Minzdrav of Russia 630091. Novosibirsk, Krasny av., 52
4Novosibirsk State Medical University of Minzdrav of Russia 630091. Novosibirsk, Krasny av., 52
5Novosibirsk State Medical University of Minzdrav of Russia 630091. Novosibirsk, Krasny av., 52
63 Scientific Center of Clinical and Experimental Medicine of SB RAMS 630117, Novosibirsk, Timakov str., 2
Abstract
Summary. The aim was to study the pathological changes in the placenta and VEGF expression in the cells of acroteric villus in case of inherited thrombophilia. For the study, samples were taken from 37 placentas of women, divided into 3 groups: the group 1 comprised 13 pregnant women with verified inherited thrombophilia (35.3 %); the group 2 included 14 pregnant women with inherited thrombophilia and signs of inflammatory manifestations in the placenta (basal deciduitis, intervillesitis, placentitis) (37.84 %); the third (control) group included 10 pregnant women with normal pregnancy. Morphological manifestations of chronic placental insufficiency in the form of pathological immaturity with a predominance of differentiated intermediate villi and dissociated maturation cotyledons with a substantial reduction of the specialized terminal villi have been revealed in placenta at hereditary thrombophilia. Decrease in the number of capillaries in the terminal villi was due to reduced expression of vascular endothelial growth factor in cells of terminal villi.
Key words
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About Authors (Correspondence):
Nadeev A.P. - doctor of medical sciences, professor of the department for pathology, e-mail: nadeevngma@mail.ru
Drobinskaya A.N. - candidate of medical sciences, deputy chief
Zhukova V.A. - candidate of medical sciences, assistant professor of the department for pathology
Karpov M.A. - candidate of medical sciences, assistant of the department for pathology
Travin M.A. - candidate of medical sciences, senior assistant professor of the department for pathology, e-mail: mtravin@mail.ru
Cherdantseva L.A. - candidate of medical sciences, senior researcher of the laboratories for pathology
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