The Siberian Scientific Medical Journal
 
 
№ 5 / 2013 / 18-24

Effects of naturally occuring highly mineralized water on human keratinocytes in vitro

Author Affiliations

Abstract

Naturally occurring highly mineralized water is widely used in skin diseases treatment. At the same time, mechanisms underlying its effects on human skin cells are poorly understood. In the present study the brine from Maloe Ostrovnoe Lake in non cytotoxic concentrations had been shown to induce cell cycle arrest in G0/G1 phase followed by attenuation of cell proliferation and increased expression of differentiation markers: loricrin and filaggrin. This observation shows onset of keratinocyte terminal differentiation, and could be used for modulation of inflammatory processes in epidermis associated with dysregulation and/or desynchronisation of cellular proliferation and differentiation.

Key words

mineral water, hyperosmotic stress, differentiation, keratinocytes, proliferation
References
About Authors (Correspondence):

Zaytseva N.S. – researcher of laboratory of cell physiology and pathology molecular mechanisms, e-mail: nszaitseva@gmail.com

Chechushkov A.V. – researcher of laboratory of cell physiology and pathology molecular mechanisms, e-mail:achechushkov@gmail.com

Kozhin P.M. – researcher of laboratory of cell physiology and pathology molecular mechanisms, e-mail: kozhinpm@gmail.com

Lemza A.E. – junior researcher of laboratory of cell physiology and pathology molecular mechanisms, e-mail: lemza.ae@gmail.com

Tkachev V.O. – candidate of biological sciences, senior researcher of laboratory of cell physiology and pathology molecular mechanisms, e-mail: tkachev_victor@mail.ru

Luzgina N.G. – candidate of medical sciences, leading researcher of laboratory of cell physiology and pathology molecular mechanisms, e-mail: ngluzgina@gmail.com

Full Text

Received: 09/02/2015