№ 3 / 2014 / 119-123

Characteristic of cytokine status in panuveitis associated with chronic infections

Author: Krichevskaya G.I.¹, Tankovskiy V.E.², Davydova G.A.³

Abstract

Aim. To study the systemic production of cytokines in panuveitis associated with chronic infections. Materials and methods. 11 cytokines and antibodies to the human herpesviruses and Toxoplasma gondii were determined in blood serum of 26 patients. Results. In general a trend of moderate increasing of the systemic level of IL-2, IL-6, TNF-α IFN-α, IFN-γ and chemokine IL-8, unlike IL-4 and IL-10 was detected. Conclusion. The systemic increasing of pro-inflammatory and preservation of anti-inflammatory cytokines at the level of the control group were determined in panuveitis, associated with chronic herpetic and toxoplasmosis infections. The level of TNF-α was significantly increased in patients with herpesvirus-toxoplasma co-infection and IL-4 production was decreased in comparison with the group of patients infected with only herpesviruses.

Key words

Toxoplasma gondii, panuveitis, human herpesviruses, cytokines

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About Authors (Correspondence):

Krichevskaya G.I. – candidate of medical sciences, leading researcher of laboratory of immunology and virology, e-mail: gkri@ yandex.ru

Tankovskiy V.E. – doctor of medical sciences, senior researcher

Davydova G.A. – candidate of medical sciences, ophthalmologist

Full Text

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Received: 10/02/2015