Morphofunctional activity of the neutrophils infected by hantaviruses
The data on definition of the functional activity of the neutrophils infected by the Hantaviruses have been presented. The enzymes – 5’-nucleotidase, adenosine triphosphatase, lactate dehydrogenase, myeloperoxidase, cytochrome c oxidase and the cationic proteins have been studied. It has been revealed that the Hantavirus is capable to infect the neutrophils, has evident influence to their oxygen forming activity. Thus the tendency to anaerobic energy production pathway in the cells has been revealed, that agrees with the increase in the LDH и CCO activity. Whereas a low MPO activity in the neutrophils infected by the Hantavirus indicates the suppression of the cell protection reaction upon the virus introduction. The Hantavirus ability to adhere to the neutrophils surface and change their morphological and functional characteristics was confirmed by the scanning electron microscopy.
About Authors (Correspondence):
Lyapun I.N. – junior researcher of the laboratory of pathomorphology and electron microscopy, е-mail: firstname.lastname@example.org
Plekhova N.G. – doctor of biological sciences, head of the laboratory of pathomorphology and electron microscopy, e-mail: email@example.com
Kompanets G.G. – candidate of medical sciences, leading researcher of the laboratory of hemorrhagic fever with renal syndrome, e-mail: firstname.lastname@example.org
Smirnov I.S. – postgraduate student of the laboratory interdisciplinary of electron microscopy and image processing, e-mail: email@example.com
Somova L.M. – doctor of medical sciences, professor, chief researcher of the laboratory of pathomorphology and electron microscopy, e-mail: firstname.lastname@example.org