The Siberian Scientific Medical Journal
 
 
№ 1 / 2014 / 15-20

Easily pass through biological membranes soapy amphiphilic inducer of interferon γ – the promising drug for treatment of human hepatitis C

Author Affiliations

Abstract

The interferon inducing activity of a soapy amphiphilic complex of a high-polymeric single-stranded RNA from Saccharomyces cerevisiae, containing short double-stranded regions with oleic acid has been studied (the Vitalang-2 drug). It was discovered that the complex is capable of crossing the biological membranes and it induces biosynthesis of IFN-γ in the animal models in a dose-dependent manner. The antiviral activity of the Vitalang-2 against human hepatitis C on the model of bovine viral diarrhea-mucosal disease in cattle (BVD-MD) is investigated. It was found that the maximum tolerated drug in a dose of 5 mg/cm3 has a profound inhibitory effect on BVD-MD virus, in cultured coronary calf cell lines; virus reduction rate was 1.97 lg10TTsD50/cm3. Therefore the study demonstrated that Vitalang-2 has antiviral activity against a BVD-MD virus in cattle, and thus it can be expected that this drug will be effective against hepatitis C in human patients.

Key words

virus diarrhea-mucosal disease, high-polymeric RNA, hepatitis C, yeast, interferon-γ, interferon inducing activity of RNA, oleic acid
References
About Authors (Correspondence):

Yamkovaya T.V. – candidate of biological sciences, director, e-mail: yam_tv@mail.ru

Glotova T.I. – doctor of biological sciences, professor, e-mail: t-glotova@mail.ru

Kolesnikova O.P. – doctor of medical sciences, head of the laboratory of experimental immunotherapy, e-mail: iscreen2001@mail.ru

Semenova O.V. – candidate of biological sciences, director, e-mail: k-olga-83@mail.ru

Gavrilova E.D. – candidate of biological sciences, e-mail: edav.gavr@mail.ru

Goiman E.V. – candidate of biological sciences, e-mail: l.goiman@mail.ru

Yamkovoy V.I. – doctor of biological sciences , professor of the chair for chemistry, e-mail: vitalang2@mail.ru

Panin L.E.– doctor of medical sciences, professor, academician of RAMS, e-mail: ibch@soramn.ru

Full Text

Received: 10/02/2015
Accepted: 07/05/2015