Antiedematous effect of the dihydroquercetin and arabinogalactan composition in chronic venous insufficiency model
Abstract
Antiedematous activity of the dihydroquercetin and arabinogalactan composition in animal model of chronic venous insufficiency induced by partial occlusion of the caudal vena cava was investigated. Course (14 days) intragastric administration of composition based on dihydroquercetin and arabinogalactan (50+250 mg/kg, respectively) was given. Antiedematous effect of the dihydroquercetin and arabinogalactan composition was evaluated by oncometry and morphological methods. Microcirculation in the tissues of the leg was measured by laser Doppler flowmetry. Venous pressure in the vena cava was recorded by the direct method on the apparatus for electrophysiological studies «Biopac». Edema of lower limbs, venous hypertension and reduction in cutaneous microcirculation was found on rat´s model of chronic venous insufficiency. It was established that course intragastric administration of dihydroquercetin and arabinogalactan composition prevented increase in the hindlimb´s circumference and area of the interstitial space, reduced venous pressure and improved microcirculation in rats with chronic venous insufficiency.
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Shamanaev A.Yu. – postgraduate student of the laboratory for pharmacology circulation, е-mail: sham_man@mail.ru
Ivanov I.S. – candidate of biological sciences, researcher of the laboratory for pharmacology circulation, е-mail: ivanov.tomsk@gmail.com
Sidekhmenova A.V. – candidate of medical sciences, researcher of the laboratory for pharmacology circulation, е-mail: sidehmenova@yandex.ru
Plotnikov M.B. – doctor of biological sciences, professor, head of the laboratory for pharmacology circulation, е-mail: mbp2001@mail.ru