№ 5 / 2014 / 22-26

Antiedematous effect of the dihydroquercetin and arabinogalactan composition in chronic venous insufficiency model

Author: Shamanaev A.Yu.¹, Ivanov I.S.², Sidekhmenova A.V.³, Plotnikov M.B.⁴

Abstract

Antiedematous activity of the dihydroquercetin and arabinogalactan composition in animal model of chronic venous insufficiency induced by partial occlusion of the caudal vena cava was investigated. Course (14 days) intragastric administration of composition based on dihydroquercetin and arabinogalactan (50+250 mg/kg, respectively) was given. Antiedematous effect of the dihydroquercetin and arabinogalactan composition was evaluated by oncometry and morphological methods. Microcirculation in the tissues of the leg was measured by laser Doppler flowmetry. Venous pressure in the vena cava was recorded by the direct method on the apparatus for electrophysiological studies «Biopac». Edema of lower limbs, venous hypertension and reduction in cutaneous microcirculation was found on rat´s model of chronic venous insufficiency. It was established that course intragastric administration of dihydroquercetin and arabinogalactan composition prevented increase in the hindlimb´s circumference and area of the interstitial space, reduced venous pressure and improved microcirculation in rats with chronic venous insufficiency.

Key words

arabinogalactan, venous pressure, microcirculation, dihydroquercetin,, edema, chronic venous insufficiency

References

1. Bogachev V.Yu. Modern pharmacotherapy of chronic venous disease of the lower extremities // Farmatsevticheskiy vestnik. 2002. (12). 21–22. (in Russian)

2. Bogachev V.Yu. Systemic pharmacotherapy of chronic venous insufficiency of the lower extremities // Russkiy meditsinskiy zhurnal. 2004. (17). 994–999. (in Russian)

3. Gorokhovskaya G.N., Yun V.L. Edema in chronic venous insufficiency of the lower extremities: clinical manifestations, medical and surgical treatment // Terapevticheskiy arkhiv. 2013. 85. (4). 93–96. (in Russian)

4. Ivanov I.S., Sidekhmenova A.V., Anishchenko A.M. et al. Pharmacological activity of composition on the base of dihydroquercertin and lipoic acid // Bulleten' sibirskoy meditsiny. 2011. (1). 43–48. (in Russian)

5. Kirienko A.I., Grigoryan R.A., Zolotukhin I.A. Modern principles of treatment of chronic venous insufficiency // Consilium medicum. 2003. 5. (6). 361—366. (in Russian)

6. Kolkhir V.K., Tyukavkina N.A., Bykov V.A. et al. Dicvertin – a new antioxidant and capillary-protecting agent // Pharm. Chem. J. 1995. (9). 57–60. (in Russian)

7. Patent 2421215 RF. Composition with improved pharmacological activity based on dihydroquercetin and plant polysaccharides (variants) / Dushkin A.V., Kolesnik Yu.A., Babkin V.A. et al.; published 15.04.2010. (in Russian)

8. Plotnikov M.B., Ivanov I.S., Sidekhmenova A.V. et al. Developing a model of chronic venous insufficiency of the lower limbs // Biomeditsina. 2013. (1). 55–66. (in Russian)

9. Guidelines for preclinical studies of drugs. Part one. M.: Grif i K, 2013. 944 p. (in Russian)

10. Savel´yev V.S. Phlebology. M. 2001. 660 p. (in Russian)

11. Stoyko Yu.V. Phlebotonic in the treatment of chronic venous insufficiency of the lower extremities // Lechashchiy vrach. 2005. (8). 46–50. (in Russian)

12. Bergan J.J., Geert M.D., Schmid-Schönbein G.W. et al. Chronic Venous Disease // N. Engl. J. Med. 2006. 355. (5). 488–498.

13. Lyseng-Williamson K.A., Perry C.M. Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids // Drugs. 2003. 63. (1). 71–100.

About Authors (Correspondence):

Shamanaev A.Yu. – postgraduate student of the laboratory for pharmacology circulation, е-mail: sham_man@mail.ru

Ivanov I.S. – candidate of biological sciences, researcher of the laboratory for pharmacology circulation, е-mail: ivanov.tomsk@gmail.com

Sidekhmenova A.V. – candidate of medical sciences, researcher of the laboratory for pharmacology circulation, е-mail: sidehmenova@yandex.ru

Plotnikov M.B. – doctor of biological sciences, professor, head of the laboratory for pharmacology circulation, е-mail: mbp2001@mail.ru

Full Text

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Received: 08/02/2015