The Siberian Scientific Medical Journal
 
 
№ 6 / 2014 / 13-16

Matrixs metalloproteinases-2 and 9 in plasma of bone marrow aspirates of patients with acute myeloid leukemia

Author Affiliations

Abstract

Aim. To determine MMP-2 and MMP-2 levels in aspirate’s plasma of bone marrow of patients with acute myeloid leukemia and to evaluate their prognostic significance. Methods. The level of MMP-2 and MMP-9 were studied in 76 patients (32 in complete remission ad 44 in non complete remission). ELISA kits (R&D systems) were used. Results and discussion. The level of MMP-2 and MMP-9 at the period of AML diagnosis was lower than in complete remission (р = 0.0001). The level increased in complete remission and decreased in relapse. Conclusion. The level of MMP-2 and MMP-9 are perspective markers to determine the volume of residual disease during the treatment of patients with acute myeloid leukemia. 

Key words

matrix metalloproteinase-2, matrix metalloproteinase-9, acute myeloid leukemia.
References
About Authors (Correspondence):

Lesnichenko I.F. – candidate of biological sciences, researcher of biochemical laboratory, e-mail: RNIIHT@mail.ru

Gritsaev S.V. – doctor of medical sciences, chief researcher of clinical department for hematology, e-mail: gritsaevsv@mail.ru

Kostroma I.I. – junior researcher of clinical department for hematology, e-mail: RNIIHT@mail.ru

Full Text

Received: 08/02/2015
Accepted: 11/05/2015