Optimization of erosive colon lesions hemoblastoses treatment: clinico-endoscopical, microbiological and immunohistochemical features of intervention
Author Affiliations1Research Institute of Haematology, Transfusiology and Intensive Therapy of Samara State Medical University of Minzdrav of Russia 443099, Samara, Chapayevskay str., 89
2Research Institute of Haematology, Transfusiology and Intensive Therapy of Samara State Medical University of Minzdrav of Russia 443099, Samara, Chapayevskay str., 89
3Research Institute of Haematology, Transfusiology and Intensive Therapy of Samara State Medical University of Minzdrav of Russia 443099, Samara, Chapayevskay str., 89
Abstract
The purpose of the study was to optimize the treatment of erosive colitis by applying the regimens with dibicorum at the patients with hemoblastosis undergoing polychemotherapy (PCT). The dibicorum (taurine) administration in the erosive lesions of colon mucosa treatment scheme of the patients with hemoblastosis within 4 weeks against the backdrop of PCT is accompanied with the higher degree of clinical effectiveness of colorectal disorders treatment. The degree of intestinal microbiocenosis recovery and processes characterizing cellular turnover of colon cells (apoptosis activity, Ki-67 expression of molecules and TLP) in the patients undergoing dibicorum treatment was significantly higher than in the patients undergoing treatment without dibikor. The latter can be explained by the cytoprotective and anti-inflammatory effects of dibicorum.
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About Authors (Correspondence):
Gritsenko T.A. – hematologist, applicant of the chair for hospital therapy with the course of transfusiology, e-mail: taras876@mail.ru
Davydkin I.L. – doctor of medical sciences, head of the chair for hospital therapy with the course of transfusiology, e-mail: dagi2006@rambler.ru
Osadchuk A.M. – professor of the chair for hospital therapy with the course of transfusiology, e-mail: maxlife2004@mail.ru
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