Optimization of erosive colon lesions hemoblastoses treatment: clinico-endoscopical, microbiological and immunohistochemical features of intervention
Author Affiliations1Research Institute of Haematology, Transfusiology and Intensive Therapy of Samara State Medical University of Minzdrav of Russia 443099, Samara, Chapayevskay str., 89
2Research Institute of Haematology, Transfusiology and Intensive Therapy of Samara State Medical University of Minzdrav of Russia 443099, Samara, Chapayevskay str., 89
3Research Institute of Haematology, Transfusiology and Intensive Therapy of Samara State Medical University of Minzdrav of Russia 443099, Samara, Chapayevskay str., 89
Abstract
The purpose of the study was to optimize the treatment of erosive colitis by applying the regimens with dibicorum at the patients with hemoblastosis undergoing polychemotherapy (PCT). The dibicorum (taurine) administration in the erosive lesions of colon mucosa treatment scheme of the patients with hemoblastosis within 4 weeks against the backdrop of PCT is accompanied with the higher degree of clinical effectiveness of colorectal disorders treatment. The degree of intestinal microbiocenosis recovery and processes characterizing cellular turnover of colon cells (apoptosis activity, Ki-67 expression of molecules and TLP) in the patients undergoing dibicorum treatment was significantly higher than in the patients undergoing treatment without dibikor. The latter can be explained by the cytoprotective and anti-inflammatory effects of dibicorum.
Key words
References1. Bulieva N.B. Opportunistic infections when epidemiology hemoblastoses // Meditsinskiy al'manakh. 2011. (5). 132-137. (in Russian)
2. Loginov A.S., Parfenov A.I. Bowel disease. Moscow, 2000. 632 p. (in Russian)
3. Osadchuk A.M., Detuchenko V.P., Milova-Filippova L.A., Kvetnoy I.M. Effect of therapy on eradication of Helicobacter pylori with dibicorum on indices of cellular homeostasis (Ki-67, Bcl-2 and apoptosis) epithelial cells of the stomach with duodenal ulcer disease // Rossiyskiy zhurnal gastroenterologii, gepatologii i coloproctologii. 2008. (3). 55-61. (in Russian)
4. Poleviсenko E.V. Alimentary mucositis of cancer patients: new ways of nutritional support // Lechashchiy vrach. 2009. (8). 81-83. (in Russian)
5. Teletaeva G.M. Cytokines and antitumor immunity // Prakticheskaya onkologiya. 2007. 8. (4). 211-218. (in Russian)
6. Shestopalova E.l. Clinical effectiveness of taurine in the complex treatment of chronic gastritis and ulcers stomach and duodenal ulcers associated with Helicobacter pylori infection: abstract of thesis…candidate of medical sciences. Volgograd, 2008. (in Russian)
7. Barasch A., Peterson D.E. Risk factors for ulcerative mucositis in cancer patients: Unanswered questions // Oral Oncol. 2003. 39. (2). 91–100.
8. Gruson D., Hilbert G., Boiron J.M. et al. Severe respiratory failure requiring ICU admission in bone marrow transplants recipients // Eur. Respir. J. 2009. 13. 883–887.
9. Sonis S.T., Elting L.S., Keefe D. et al. Perspectives on cancer therapy induced mucosal injury: pathogenesis, measurement, epidemiology and consequences for patients // Cancer. 2004. 100. (9, Suppl.). 1995–2025.
10. Tarro G., Perna A., Esposito C. et al. Early diagnosis of lung cancer by detection of tumor liberated protein // J. Cell. Physiol. 2005. 203. 1–5.
About Authors (Correspondence):
Gritsenko T.A. – hematologist, applicant of the chair for hospital therapy with the course of transfusiology, e-mail: taras876@mail.ru
Davydkin I.L. – doctor of medical sciences, head of the chair for hospital therapy with the course of transfusiology, e-mail: dagi2006@rambler.ru
Osadchuk A.M. – professor of the chair for hospital therapy with the course of transfusiology, e-mail: maxlife2004@mail.ru
Full Text