The Siberian Scientific Medical Journal
№ 5 / 2013 / 64-69

Modification of fatty acid content of cell membranes of erythrocytes at chronic obstructive pulmonary disease

Author Affiliations


20 patients with mild chronic obstructive pulmonary disease (COPD) in remission and 20 healthy people have been examined in order to study the fatty acid composition of the membranes of red blood. The fatty acid composition of erythrocyte membranes was studied by gas-liquid chromatography. It has been revealed that the modification of fatty acid composition of erythrocyte membranes characterized by the accumulation of saturated (15:0, 18:0, 20:0), n6 polyunsaturated (20:4 n6, 22:4 n6), deficiency of n3 polyunsaturated (20:5 n3, 22 : 5n3) fatty acids is observed in patients with COPD. The pathogenetic basis of this modification is a violation of their metabolism. Thus, disruption of the lipid components of the cell membrane is an important link of the COPD pathogenesis.

Key words

fatty acids, cell membrane, chronic obstructive pulmonary disease
About Authors (Correspondence):

Novgorodtseva T.P. – doctor of biological sciences, professor, deputy director, e-mail:

Denisenko Yu.K. – doctor of biological sciences, head of the laboratory of biomedical researches, e-mail:

Antonyuk M.V. – doctor of medicine sciences, professor, head of the laboratory for medical rehabilitation, e-mail:

Zhukova N.V. – doctor of biological sciences, docent, senior researcher, e-mail:

Full Text

Received: 09/02/2015