Activity of oxidative stress and the levels of proinflammatory interleukins at uterus cancer in women
In order to examine the content of lipid peroxidation products, fat-soluble antioxidants and anti-inflammatory interleukins in blood of women with cancer of the uterine body 290 patients with adenocarcinoma (I–IV stages) and 45 women without signs of inflammatory and neoplastic diseases have been examined. The results indicate that malondialdehyde content increased by 49.8% and fat-soluble antioxidants (β-carotene, retinol, α-tocopherol) concentration reduced by more than 30% in serum of patients with cancer of uterine body compared to healthy women. As a specific characteristic of tumor growth in patients with adenocarcinoma, more than two-fold increase in the concentration of pro-inflammatory IL-1b and IL-6 in the blood has been revealed. The data presented clearly demonstrate that one of the important mechanisms of the pathogenesis of uterine body neoplastic diseases is oxidative stress, characterized by increasing levels of lipid peroxidation products and depletion of antioxidant capacity, and a high pro-inflammatory cytokine activity.
About Authors (Correspondence):
Safronov I.D. – doctor of medical sciences, professor, leading researcher, professor of the chair of pathophysiology, e-mail: firstname.lastname@example.org
Trunov A.N. – doctor of medical sciences, professor, head of the laboratory of immunology, professor of the chair of pathophysiology, e-mail: email@example.com
Efremov A.V. – doctor of medical sciences, professor, corresponding member of RAMS, head of chair for pathophysiology, e-mail: firstname.lastname@example.org