The liver regional lymph nodes of rats in conditions of functional epiphysectomy aggravated by ethanol intoxication

The influence of functional epiphysectomy aggravated by chronic ethanol intoxication on morphological organization of the liver regional lymph nodes of rats has been studied. It is shown that combination of the investigated destabilizing factors causes strengthening of the B-dependent immune response intensity - the increase in specific volume density of the lymphoid nodules, the percentage growth of the germinative centers in them, strengthening the blast cell formation in the germinative centers, the increase in the number of medium and small lymphocytes in the medullary cords. The decrease in the relative size of the paracortical zone and the reduction in the number of blasts in it testify to suppression of activity of the T-dependent immune reactions. In addition combination of destabilizing factors leads to disruption of the reticular frame ultrastructure, which performs the function of a communicative network in a lymph node, causes the loss of antigen-presenting abilities of interdigitating dendritic cells and fibroblastic reticular cells in the paracortical zone, leads to exhausting stocks of the plasma cells with active immunoglobulinsynthesizing function in the medullary cords. Significant ultrastructural changes in the lymph nodes are aggravated by lack of their drainage function. These described facts testify to the adaptation possibilities failure of the liver regional lymph nodes.

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Ishchenko I.Yu. - candidate of biological sciences, senior researcher of the laboratory of lymphatic system functional morphology, е-mail: irenisch@mail.
Michurina C.V. - doctor of medical sciences, professor, chief researcher of the laboratory of lymphatic system functional morphology