The Siberian Scientific Medical Journal
№ 4 / 2013 / 5-11

Peculiarities of lipid and glucose metabolism in hypertensive rats of strain ISIAH

Author Affiliations


The work was aimed at the comparative study of serum lipid profile, glucose, corticosterone, TNF-a, IL6, liver PPAR-a and -g DNA-binding activity and blood pressure levels in six-monthly hypertensive rats of ISIAH strain and normotensive rats of WAG strain under normal conditions and by high-fat diet, injection of E. coli lipopolysaccharide (LPS), bezafibrate, and constant light have been studied. It was found that most studied indices in intact ISIAN rats are distinguished from WAG rats significantly. In contrast to WAG rats, high-fat diet did not lead to sign development of metabolic syndrome in ISIAH rats which however were more sensitive to LPS and bezafibrate exposure and less responsive to constant light. Thus, the ISIAH rats may be a genetic model to uncover novel mechanisms of resistance to metabolic syndrome, hypersensitivity to inflammatory stimuli and adaptation resources of organism.

Key words

PPAR, bacterial endotoxin, hypertensive ISIAN rats, desynchro­nosis, high-fad diet, corticosterone., lipid and glucose metabolism
About Authors (Correspondence):

Kovshik G.G. – postgraduate student, e-mail:

Khrapova M.V. – candidate of biological sciences, senior researcher, e-mail:

Dushkin M.I. – doctor of medical sciences, professor, head of laboratory for molecular and cellular mechanisms, e-mail:

Full Text

Received: 01/02/2015