The Siberian Scientific Medical Journal
 
 
№ 6 / 2014 / 76-81

Study of clinical and laboratory significance of myelofibrosis in multiple myeloma

Author Affiliations

Abstract

The inverse correlations between the prevalence of myelofibrosis and the total number of erythroid cells and megakaryocytes, as well as hemoglobin level were found in multiple myeloma. The direct correlations between relative area of fibrous tissue and relative area of tumor tissue, between relative area of fibrous tissue and the level of total serum protein, between relative area of fibrous tissue and daily proteinuria were found both in initial and in advanced myelofibrosis. Additionally, a direct correlation between relative area of fibrous tissue and the number of plasma cells was revealed in initial myelofibrosis. Greater relative area of fibrous tissue in initial and advanced myelofibrosis was found in patients with chronic renal failure.

Key words

anemia, myelofibrosis, multiple myeloma, tumor progression
References
About Authors (Correspondence):

Domnikova N.P. – doctor of medical sciences, professor, head of laboratory of molecular cellular and immunomorphological basis of oncohematology, head of hematology department with aseptic wards, e-mail: n_domnikova@mail.ru

Dolgikh T.Yu. – candidate of medical sciences, senior researcher, physician of hematology department with aseptic wards, e-mail: tatyana.yurevna.dolgikh@yandex.ru

D’yachkova Yu.A. – postgraduate student, physician of hematology department with aseptic wards, e-mail: dyachkova_yuliya@mail.ru

Maltseva N.A. – researcher, laboratory doctor, e-mail: pathol@soramn.ru

Kachesov I.V. – head of department of pathological anatomy, e-mail: pathol@soramn.ru

Marchenko A.A. – physician of department of pathological anatomy, e-mail: pathol@soramn.ru

Full Text

Received: 12/02/2015