Study of the anterior eye segment structures in applying of antiglaucoma drugs according to the ultrasound biomicroscopy

Objective: Using ultrasound biomicroscopy to evaluate the anterior eye segment changes of patients with refractory glaucoma applying local hypotensive drugs of different groups. Material and methods: 108 eyes of 104 patients divided into three groups depending on the level of intraocular pressure and hypotensive therapy. Results and discussion: The filtering bleb height in the area of filtration surgery did not have the significant difference from the control group at complex therapy in the postoperative period. UBM-indicators of conjunctival and scleral flaps thicknesses may serve only as indirect markers of elevated intraocular pressure.

1. Astakhov S.Yu., Grabovetskiy V.F., Nefedova D.M., Tkachenko N.V. Benefits and drawbacks of antihypertensive drops without preservatives // [Ophtalmologicheskie vedomosti]. 2011. V. 4, № 2. P. 95 – 97. (in Russian)

2. Balashevich L.I., Kachanov A.B., Nikulin S.A. et al. The corneal thickness effect on the pneumotonometric indicators of intraocular pressure // Ophtalmohirurgiya [Ophtal'mosurgery]. 2005. № 1. P. 31 – 33. (in Russian)

3. Gusarevich O.G., Gusarevich A.A., Nurlanbayeva A.E., Aidagulova S.V. Medicamental therapy of refractory glaucoma: the present and the future // Russkii Medicinskii Zhurnal, Klinicheskaya ophtalmologiya [Russian Medical Journal, Clinical ophthalmology]. 2014. № 2. P. 64 – 68. (in Russian)

4. Kuleshova O.N., Nepomnyashchikh G.I., Aidagulova S.V. Analysis of morphological changes of uxtacanalicular tissue and sclera at the operational material in juvenile and primary open-angle glaucoma // Ophalmohirurgiya [Ophtal'mosurgery]. 2008. № 3. P. 12 – 15. (in Russian)

5. Fenkova O.G., Fursova A.Zh., Gusarevich O.G. Clinical-morphological and functional criteria for assessing the severity of congenital glaucoma // Russkii Medicinskii Zhurnal, Klinicheskaya ophtalmologiya [Russian Medical Journal, Clinical ophthalmology]. 2011. № 2. P.  56 - 58. (in Russian).

6. Shchuko A.G., Zhukova S.I., Yur'eva T.N. Ultrazvukovaya diagnostica v ophtalmologii [Ultrasound diagnostics in ophtalmology]. Мoscow, Ophthalmology Publ., 2013. 128 p. (in Russian)

7. Bettin P., Di Matteo F. Glaucoma: present challenges and future trends // Ophthalmic Res. 2013. 50. (4). 197–208.

8. Dreer L.E., Girkin C., Mansberger S.L. Deter­minants of medication adherence to topical glaucoma therapy // J. Glaucoma. 2012. 21. (4). 234–240.

9. Golez E., Latina M. The use of anterior segment imaging after trabeculectomy // Semin. Ophthalmol. 2012. 27. (5-6). 155–159.

10. Kerr N.M., Patel H.Y., Chew S.S. et al. Patient satisfaction with topical ocular hypotensives // Clin. Exp. Ophthalmol. 2013. 41. (1). 27–35.

11. Mostafavi D., Nagel D., Danias J. Haptic-induced postoperative complications. Evaluation using ultrasound biomicroscopy // Can. J. Ophthalmol. 2013. 48. (6). 478–481.

12. Salim S., Dorairaj S. Anterior segment imaging in glaucoma // Semin. Ophthalmol. 2013. 28. (3). 113–125.

Aidagulova S.V. – doctor of biological sciences, professor, head of the laboratory for cellular biology and fundamental basis of reproduction, e-mail: a_sv@ngs.ru