The Siberian Scientific Medical Journal
 
 
№ 4 / 2013 / 77-84

Microecological combinations of vaginal and intestinal biotopes in women with lower female reproductive tract inflammantory diseases and in adolescents girls with ovarian dysfunction

Author Affiliations

Abstract

Objective – to study the influence of dysbiotic changes of intestinal microbiota on vaginal microbiocenosis and to evaluate the effectiveness of complex correction of dysbiotic changes simultaneously in two biotopes: intestine and vagina on a background of basic therapy in women with nonspecific inflammatory of the lower female reproductive tract diseases. The study included 205 patients: 60 adolescent girls with ovarian dysfunction (13–15 years old) and 145 women of reproductive age (25–45 years) with nonspecific lower female reproductive tract inflammatory, which in turn were divided into 2 comparison groups: 59 patients received the standard etiotropic therapy with the correction of imbalance in the vaginal microbiocenosis; additionally the correction of dysbiotic changes in intestine was added to ongoing therapy of 55 patients. The examination included standard clinical and laboratory methods: bacterioscopic, molecular biology (PCR), vaginal discharge culture study before and after therapy, and study of the intestine microbiota. The high detection rate of clinically important opportunistic microorganisms in the vaginal biotopes in the cases of profound bifido- and lactobacterias deficiency in intestinal biotopes has been registered. The combined intestinal and vaginal biocenosis correction has shown the expressed effectiveness of the patients’ treatment in comparison with the mono-correction.

Key words

vaginal microbiocenosis, vaginal microbiocenosis, intestinal biotope, correction, intestinal biotope, correction
References
About Authors (Correspondence):

Popkova S.M. – doctor of biological sciences, head of the laboratory for microecology, e-mail: smpopkova@gmail.com

Rakova E.B. – candidate of biological sciences, researcher of the laboratory for microecology, e-mail: lenova_@mail.ru

Khramova E.E. – candidate of medical sciences, head of department of adolescent gynecology, e-mail: aelita-82@mail.ru

Danusevich I.N. – candidate of medical sciences, researcher of the laboratory of endocrinology and gynecology, e-mail: irinaemails@gmail.com

Shabanova N.M. – junior researcher of the laboratory for microecology, e-mail: n.m.shabanova@mail.ru

Serdjuk L.V. – candidate of biological sciences, researcher of the laboratory for microecology, e-mail: radugarose@yandex.ru

Nemchenko U.M. – junior researcher of the laboratory for microecology, e-mail:lav0467@mail.ru

Ivanova E.I. – junior researcher of the laboratory for microecology, e-mail:ivanova.iem@gmail.com

Full Text

Received: 01/02/2015