Immunotropic activity of soapy amphiphilic high-polymer rna from baker’s yeast

The immunotropic activity of the amphiphilic high-polymer RNA isolated from baker’s yeast with oleic acid has been studied. It was discovered that the drug dose-dependently increases the mass of lymphoid organs (thymus and spleen) in mice, as well increases the average number of cells in these organs. The drug induces leukocyte reaction, dose-dependently stimulates the primary (IgM) and secondary (IgG) antibody response. However, it has an immunosuppressive effect on the expression of cell-mediated immune response (dose-dependent suppression of the effector phase of delayed-type hypersensitivity reactions and pronounced suppression phase of sensitization in the high dose).

Yamkovaya T.V. – candidate of biological sciences, director, e-mail: yam_tv@mail.ru

Kolesnikova O.P. – doctor of medical sciences, head of the laboratory of experimental immunotherapy, e-mail: iscreen2001@mail.ru

Yamkovoy V.I. – doctor of biological sciences, professor of the chair for chemistry , e-mail: vitalang2@mail.ru

Kozlov V.A. – academician of the RAMS, doctor of medical sciences, professor, director, e-mail: iscreen2001@mail.ru

Panin L.E. – doctor of medical sciences, professor, academician of the RAMS, director, e-mail: ibch@soramn.ru