IL1B and IL6 gene polymorphism in endometriosis-related infertility
Author Affiliations1Institute of Obstetrics, Gynecology and Perinatology of SB RAS 634063, Tomsk, Sergey Lazo str., 5
2Siberian State Medical University of Minzdrav of Russia 634050, Tomsk, Moscovskiy tract, 2
3Siberian State Medical University of Minzdrav of Russia 634050, Tomsk, Moscovskiy tract, 2
4Institute for Obstetrics, Gynaecology and Perinatology of SB RAMS 634063, Tomsk, Lazo str., 5
5Siberian State Medical University of Minzdrav of Russia 634050, Tomsk, Moskovskiy tract, 2
6Siberian State Medical University of Minzdrav of Russia 634050, Tomsk, Moscovskiy tract, 2
7Siberian State Medical University of Minzdrav of Russia 634050, Tomsk, Moscovskiy tract, 2
8Siberian State Medical University of Minzdrav of Russia 634050, Tomsk, Moscovskiy tract, 2
Abstract
Clinical, molecular and genetic examination of 145 patients with the genital endometriosis, suffering infertility has been conducted. It is registered that distribution of allelic variants of cytokine genes among patients with endometriosis associated infertility is characterized by prevalence of genotypes of TT of a polymorphic site of C511T of a gene of IL1B and the CC polymorphism of G-174C of a gene of IL6. The positive association of endometriosis connected with infertility with allele in T and a genotype of a TT of polymorphism of C511T of a gene of IL1, and also with allele C and a genotype of the CC polymorphism of G-174C of a gene of IL6 is revealed.
Key words
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About Authors (Correspondence):
Agarkova T.A. - practicing doctor obstetrician-gynecologist, e-mail: agarkina@mail.ru
Kublinskiy K.S. - candidate of medical sciences, clinical gynaecologist, e-mail: kublinskiy@sibmail.com
Naslednikova I.O. - doctor of medical sciences, professor of the chair for pathophysiology, е-mail: ira_naslednikova@mail.ru
Evtushenko I.D. - doctor of medical sciences, professor, head of the chair for obstetrics and gynaecology, e-mail:. evtushenko_1d@mail.ru
Agarkova L.A. - doctor of medical sciences, professor, director, e-mail: general@rd4.tomsk.ru
Novitskiy V.V. - rector, academician of RAMS, doctor of medical sciences, professor, head of the chair for pathophysiology, е-mail: ira_naslednikova@mail.ru
Il'yadi Ye.B. - postgraduate student of the chair for pathophysiology, е-mail: ira_naslednikova@mail.ru
Urazova O.I. - doctor of medical sciences, professor of the chair for pathophysiology, е-mail: ira_naslednikova@mail.ru
Voronkova O.V. - doctor of medical sciences, professor of the chair for pathophysiology, е-mail: ira_naslednikova@mail.ru
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