Impact of the regional lymphotropic therapy on inflammation at lung cancer
Author Affiliations1Novosibirsk Regional Cancer Center 630108, Novosibirsk, Plakhotnyy str., 2
2Institute of Clinical and Experimental Lymphology SB RAMS 630117, Novosibirsk, Timakov str., 2
3Novosibirsk State Medical University of Minzdrav of Russia 630091, Novosibirsk, Krasnyi av., 52
4Institute of Chemical Biology and Fundamental Medicine of SB RAS 630090, Novosibirsk, Akademik Lavrentiev av., 8
Abstract
Tumor of trachea, bronchi and lungs takes the first place in the structure of mortality from malignant neoplasms in Russia. Taking into consideration the influence of certain interleukins on cancer occurrence, development and course, the investigation of changes in the content of interleukins IL-l , IL-4, IL-6, IL-8, IFN- and circulating immune complexes in blood serum of 96 patients has been carried out before and after surgery for lung cancer. The effect of different types of regional lymphotropic therapy on the course of the inflammatory process in the postoperative period has been researched. The rapid relief of symptoms of inflammation in lymphotropic correction has been revealed. It leads to the reduction of IL-1 , IL-6, IL-8, IL-4 and circulating immune complexes in serum of patients by 7day of postoperative period. The rate of postoperative complications has been reduced as the result of the use of different methods of administration of complex drug mixture in lung lymph region.
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References1. Berezhnaya N.M. Role of immune system cells in the microenvironment of tumors // Onkologiya. 2009. (1). 6-17. (in Russian)
2. Kelina N.Yu., Vasilkov V.G., Bezruchko N.V. Methodology for assessing the development of biochemical evidence of endotoxemia // Vestnik intens. terapii. 2002. (4). 13-17. (in Russian)
3. Lymphology. Ed. V.I. Konenkov, Yu.I. Borodin, M.S. Lubarskiy. Novosibirsk: Manuscript, 2011. 1104 p. (in Russian)
4. Lubarsky M.S., Smagin A.A., Morozov V.V. et al. New methods of regional lymphotropic therapy in clinical practice // Byulleten' Sibirskogo Otdeleniya Rossiyskoy Akademii Meditsinskikh Nauk. 2007. (2). 65-72. (in Russian)
5. Narov Yu.E. Lymphotropic and adsorption technologies in the correction of endotoxemia in cancer of the colon and breast cancer: abstract of thesis…doctor of medical sciences. Novosibirsk, 2004. (in Russian)
6. The state of cancer care in Russia in 2011. Ed. V.I. Chissov, V.V. Starynsky, G.V. Petrova. M.: FGBU "MSREI them. P.A. Herzen "Russian Health and Social Development, 2012. 240 p. (in Russian)
7. Fursov S.A. Adsorption and lymphotropic technologies in the prevention and treatment of infectious complications and correction of endotoxemia in the postoperative period in colorectal cancer: abstract of thesis…doctor of medical sciences. Novosibirsk, 2006. (in Russian)
8. Chikinev Yu.V., Antonov A.R., Lubarskiy M.S. The role of indirect lymphotropic therapy in improving the nutritional status of patients with scar contractions of the esophagus // Vestnik novykh meditsinskikh tekhnologiy. 2004. (2). 15-16. (in Russian)
9. Menon A.G., Janssen-van Rhijn C.M., Morreau H. Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis // Lab. Invest. 2004. 84. (4). 493-501.
About Authors (Correspondence):
Zeydlits A.A. - postgraduate student, oncologist
Lubarsky M.S. - doctor of medical sciences, professor, corresponding member of RAMS, deputy director
Narov Yu.E. - doctor of medical sciences, professor, consultant
Morozov V.V. - doctor of medical sciences, professor, senior researcher, e-mail: doctor.morozov @ mail.ru
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