The Siberian Scientific Medical Journal
 
 
№ 1 / 2015 / 14-18

Effect of peptide tuftsin complex with cucurbit[7]uril on superoxide anion in vitro and in vivo

Author Affiliations

Abstract

This paper considers the influence of the immunomodulator taftsin complexed with cucurbit[7]uril on superoxide production by phagocytes. It was assumed that the molecule taftsin complexing protects against biodegradation and prolongs the effect of the peptide. It has been established that the complex has a similar effect on the superoxide production compared to the free taftsin as in vitro, and in vivo. Cucurbit[7]uril did not affect the ability of cells to produce superoxide radical.

Key words

immunomodulator, complexation, cucurbit [7] uril, peptides, superoxide radical, taftsin
References
About Authors (Correspondence):

Pashkina E.A. – junior researcher of laboratory of clinical immunopathology, e-mail: pashkina.e.a@ya.ru

Lyubimov G.Yu. – candidate of medical sciences, researcher of laboratory of immunopoiesis regulation, e-mail: glubimov@rambler.ru

Grishina L.V. – candidate of biological sciences, researcher of laboratory of clinical immunopathology, e-mail: l_grishina@bk.ru

Gerasko O.A. – doctor of chemical sciences, leading researcher of laboratory of clusters and supramolecular compounds, e-mail: olager@niic.nsc.ru

Yakushenko E.A. – doctor of medical sciences, researcher of laboratory of immunopoiesis regulation e-mail: e-yakushenko@mail.ru

Kozlov V.A. – doctor of medical sciences, academician of RAS, e-mail: niiki01@online.nsk.su

Full Text

Received: 17/02/2015