Functional metabolic state of neutrophile phagocytes in patients with long tubular bone osteomyelitis
Author Affiliations1Scientific Center of Restorative Traumatology and Orthopedics n.a. acad.G.I. Ilizarov of Minzdrav of Russia, 640014 Kurgan, M. Ulyanov str., 6
2Scientific Center of Restorative Traumatology and Orthopedics n.a. acad.G.I. Ilizarov of Minzdrav of Russia, 640014 Kurgan, M. Ulyanov str., 6
3Scientific Center of Restorative Traumatology and Orthopedics n.a. acad.G.I. Ilizarov of Minzdrav of Russia, 640014 Kurgan, M. Ulyanov str., 6
4Scientific Center of Restorative Traumatology and Orthopedics n.a. acad.G.I. Ilizarov of Minzdrav of Russia, 640014 Kurgan, M. Ulyanov str., 6
Abstract
The state of phagocytic activity of peripheral blood neutrophils was assessed in 50 patients with chronic posttraumatic osteomyelitis of long tubular bones. The increase of neutrophils functional metabolic activity was observed in chronic osteomyelitis regardless of the activity of the inflammation process that was associated with the overall direction effect of the immune cells – an effort of pathogen inactivation and elimination by phagocytosis. During chronic osteomyelitis exacerbation an alternative extra way of controlling infection pathogens is initiated that consists in the formation of neutrophilic traps.
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About Authors (Correspondence):
Kuznetsova E.I. – junior researcher of clinical laboratory of microbiology and immunology, e-mail: citoz@mail.ru
Chepeleva M.V. – candidate of medical sciences, senior researcher of clinical laboratory of microbiology and immunology, e-mail: office@ilizarov.ru
Klyushin N.M. – doctor of medical sciences, head of the laboratory of pyogenic osteology and limb defect filling, e-mail: elenka_kgn@mail.ru
Burnashov S.I. – orthopaedic surgeon, head of bone infection department 2, e-mail: elenka_kgn@mail.ru
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