MALT-lymphoma of the stomach and chronic H. pylori-associated gastritis: clinical, endoscopic, morphological and immunohistochemical comparison
The purpose of the study. Identification of new mechanisms of the stomach MALT-lymphoma occurrence in patients with chronic H. pylori-associated with gastritis on the basis of clinical-endoscopic, morphological and immunohistochemical data. Material and methods. 49 patients with the stomach MALT-Lymphoma of I and II stages of A and B subtypes according to D. de Jong classification (1997) without t translocation in age from 60 to 74 years have been examined. Te expression of Ki-67, Bcl-2 and p53 in epithelial and lymphoid tissue of the stomach mucosa has been investigated. Results and discussion. The carried out research confirmed the existence of associative relation between progression of atrophic gastritis, increasing intestinal metaplasia severity, increase in gastric epithelial dysplasia numbers and degree of gastric mucosa lymphoid hyperplasia manifestation, which is the final stage of the stomach MALT-lymphoma formation. Thus, MALT-lymphoma of the stomach along with gastric cancer of intestinal type is the final link in the progression of chronic gastritis associated with H. pylori.
About Authors (Correspondence):
Kostalanova Yu.V. – postgraduate student of the chair for hospital therapy with transfusion course, e-mail: email@example.com
Davydkin I.L. – doctor of medical sciences, professor. chief hematologist, head of the chair for hospital therapy with transfusion course, e-mail: firstname.lastname@example.org
Koroleva I.A. – doctor of medical sciences, head of the chemotherapy ward, e-mail: email@example.com
Osadchuk A.M. – doctor of medical sciences, professor of the chair for hospital therapy with transfusion course, e-mail firstname.lastname@example.org
Gritsenko T.A. – doctor of medical sciences, professor of the chair for hospital therapy with transfusion course, e-mail email@example.com