№ 2 / 2015 / 11-15

Local hemostatic agent based on oxidized cellulose

Author: Tarkova A.R.¹, Chernyavskiy A.M.², Morozov S.V.³, Grigor’ev I.A.⁴, Tkacheva N.I.⁵, Rodionov V.I.⁶

Abstract

The definition of haemostatic activity of import-substituting haemostatic material for local acting obtained from the oxidation of non-regenerated cellulose has been carried out on models of laboratory animals (outbred rats). It was found that the investigated sample of oxidized cellulose has hemostatic activity which parameters are comparable with the known material «Surgicel» activity parameters: using the investigated sample through application to incised wound to the left lobe of the liver in rats resulted in decrease in the intensity of blood loss by 60 % on the severity of spontaneous bleeding stops, and the stop time of bleeding was 300 ± 24 s (in the case of «Surgicel» – respectively 64% and 273 ± 36 s).

Key words

hemostasis,, bleeding, oxidized cellulose, surgical intervention

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About Authors (Correspondence):

Tarkova A.R. – postgraduate student of the unit for aorta, coronary and peripheral artery surgery, e-mail: artarkova@mail.ru

Chernyavskiy A.M. – doctor of medical sciences, professor, head of the unit for aorta, coronary and peripheral artery surgery, e-mail: amchern@mail.ru

Morozov S.V. – candidate of chemical sciences, head of the laboratory of ecological research and chromatography, e-mail: morozov@nioch.nsc.ru

Grigor’ev I.A. – doctor of chemical sciences, professor, head of the laboratory of nitrogen compounds, e-mail: grig@nioch.nsc.ru

Tkacheva N.I. – candidate of chemical sciences, senior researcher of the laboratory of ecological research and chromatography, e-mail: yaroshen@nioch.nsc.ru

Rodionov V.I. – candidate of chemical sciences, head of unit, e-mail: virod@nioch.nsc.ru

Full Text

2-2-2015.pdf

Received: 17/04/2015