The Siberian Scientific Medical Journal
№ 2 / 2015 / 16-22

Effect of novel water-soluble phenolic antioxidants on cell viability: structure-activity relationships

Author Affiliations


In order to investigate cytotoxicity of structurally similar synthetic water-soluble sulfur- and selenium-containing monophenolic antioxidants, their effect on the viability of monocyte/macrophage U937 cells has been studied in normal conditions and under oxidative stress. All tested compounds showed low toxicity (IC50 = 0.3 mM), with the exception of selenium-containing analog (IC50 = 80 mM). At that, partially hindered phenol with one ortho-tert-butyl and a bivalent sulfur atom in the para-propyl substituent TS-13 at low doses increased the number of viable cells in vitro in normal conditions and when incubated with the cytotoxic concentrations of H2O2, probably due to inhibition of the apoptotic processes.

Key words

TS-13, viability, synthetic antioxidants
About Authors (Correspondence):

Lemza A.E. – candidate of biological sciences, researcher, e-mail:

Tkachev V.O. – candidate of medical sciences, senior researcher, e-mail:

Zenkov N.K. – doctor of biological sciences, leading researcher, e-mail:

Khol’shin S.V. – sinior lecturer, e-mail:

Kandalintseva N.V. – candidate of chemical sciences, professor, e-mail:

Menshchikova E.B. – doctor of medical sciences, head of the laboratory, e-mail:

Full Text

Received: 17/04/2015