№ 2 / 2015 / 23-30

The wave characteristics of the heart rhythm of nonlinear rats at blockade peripheral and central adrenergic structures

Author: Kuryanova E.V.¹, Zhukova Yu.D.², Horst N.A.³, Zhukovina N.V.⁴

Abstract

The changes of heart rate variability (HRV) on introducing blockader of β₁-adrenoreceptors (β₁-АR) atenolol (2 mg/kg of b.w., 7 days) and blockader of catecholamines synthesis (BCS) alpha – methyltyrosine (180 mg/kg of b.w., 3 days) have been investigated in male adult rats and 1,5-month’s rats under condition of quiet wake and acute stress. The BCS causes the increase in the high frequency (HF) waves` intensity and ratio in HRV spectrum along with the reduction in ratio of low frequency (LF) and very low frequency (VLF) waves. The β₁-AR blockade performs the opposite effect as reduction in HF ratio and increases in LF and VLF ratio in HRV-spectrum in adult rats in rest. The effects of adrenergic blockade are more strongly pronounced in 5–6-week rats. As far as not only the relative capacity of HRV-waves but also the absolute capacity of waves have been changed in them: on the background of atenolol the HF waves` intensity was reduced and on the background of BCS the VLF intensity was reduced. Under stress in rats with blockade of β1-adrenoreceptors the capacity of all HRV-waves (especially HF) acutely fell down, but the high control for heart rhythm remained unchanged. On the background of BCS the capacity of HF-waves remained high, and the capacity of VLF-waves and control for heart rhythm was reduced under stress. It has been suggested that the blockade of central catecholaminergic structures causes the more pronounced and definite changes of HRV-waves, it is more effective for revealing the role of adrenergic mechanisms in formation of HRV-waves (mainly VLF), rather than blockade of myocardial β₁-adrenoreceptors which most likely participate in formation of the general variability of heart rhythm.

Key words

alpha-methyltyrosine, atenolol, blockade of β1-adrenoreceptors,, blockade of catecholamines synthesis, heart rate variability, age, High-frequency waves, HF, low-frequency waves LF, low-frequency waves VLF, spectral analysis, stress

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About Authors (Correspondence):

Kuryanova E.V. – doctor of medical sciences, professor of the chair for human and animal physiology and morphology, e-mail: fyzevk@rambler.ru

Zhukova Yu.D. – master`s student of the 2 grade

Horst N.A. – doctor of biological sciences, professor of the chair for human and animal physiology and morphology

Zhukovina N.V. – master`s student of the 2 grade

Full Text

4-2-2015.pdf

Received: 17/04/2015