The Siberian Scientific Medical Journal
№ 2 / 2015 / 43-46

The hemostatic system in rats at longtime hyperthermic load

Author Affiliations


Goal: To analyze the state of the reaction of hemostatic system in rats during long-term exposure to hyperthermia. Material and methods: Wistar rats-males (120 animals) have been used. Hyperthermia was simulated by the laboratory animals introducing into the thermal chamber (thermostat) with the inside air temperature of +45 оС at the certain time. Results and discussion: It is established that the effect of long-term adaptation of hemostasis occurs only after 30 days of daily hyperthermic exposure. Daily experimental impact on the seventh day is accompanied by increased activity of the platelet and plasma hemostasis, increased anticoagulant and inhibition of fibrinolytic system of blood. After 30 days there is a decrease in the activity of platelet and plasma hemostasis, normalization of anticoagulant and activation of the fibrinolytic system of blood.

Key words

adaptation, hemostasis,, general overheating, chronic experiment
About Authors (Correspondence):

Nikolaev V.Yu. – postgraduate student of the chair for normal physiology, junior researcher, e-mail:

Shakhmatov I.I. – doctor of medical sciences, professor, senior researcher, e-mail:

Kiselev V.I. – doctor of medical sciences, corresponding member of RAS, head of the chair for normal physiology, e-mail:

Moskalenko S.V. – student, e-mail:

Full Text

Received: 17/04/2015