Concentration of immunoglobulines and cytokines in the synovial fluid of osteoarthrosis patients in the presence or absence of clinical signs of synovitis
Author Affiliations1Scientific Center of Restorative Traumatology and Orthopedics n.a. acad.G.I. Ilizarov of Minzdrav of Russia, 640014 Kurgan, M. Ulyanov str., 6
2Russian Scientific Center for Restorative Traumatology and Orthopedics n.a. G.A. Ilizarov of Minzdrav of Russia, 640014, Kurgan, M. Ulyanova str., 6
3Scientific Center of Restorative Traumatology and Orthopedics n.a. acad.G.I. Ilizarov of Minzdrav of Russia, 640014 Kurgan, M. Ulyanov str., 6
Abstract
The content of cytokines and immunoglobulines in synovial fluid of 46 patients has been investigated in early and late stages of osteoarthritis (OA) of the knee joint in the presence and absence of clinical signs of synovitis. Quantitative determination of the concentrations of IgA, IgM, IgG, IL-1β, IL-6, TNFα, IL-10, IL-8, IFNγ was performed by emmunoenzyme method. The most pronounced immunological changes have been identified in patients with the presence of synovitis. At the same time, the higher concentrations of immunoglobulines and cytokines and clinical signs of acute synovitis in synovial fluid have been revealed in patients with early stage of osteoarthritis than in patients with osteoarthritis of stage II – III in the absence of synovitis. The following immunological parameters: IgG, IL-1β, IL-6 were the most informative in terms of diagnosis of the inflammatory process in periarticular tissues. The data obtained can be used as diagnostic and prognostic criteria in the development of inflammatory process in periarticular tissues in patients at stages of outpatient and surgical treatment of osteoarthritis.
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About Authors (Correspondence):
Chepeleva M.V. – candidate of medical sciences, senior researcher of clinical laboratory of microbiology and immunology, e-mail: office@ilizarov.ru
Sazonova N.V. – doctor of medical sciences, head of consultative diagnosis department, e-mail: nv.sazonova@yandex.ru
Kuznetsova E.I. – junior researcher of clinical laboratory of microbiology and immunology, e-mail: citoz@mail.ru
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