Cytokines and genes polymorphism in the promoter regions (C-590T IL4 and C-597A IL10) as markers of uncontrolled atopic bronchial asthma in children
The aim. To study an association between the promoter polymorphisms of the IL4 (C-590T) and IL10 (C-597A) genes and serum cytokines level in children with atopic bronchial asthma. Material and methods. The immune status parameters, serum cytokines level and gene polymorphism С-590Т IL4 and С-597А IL10 has been evaluated in seventy four children with asthma. Results and discussion. The occurrence of T-590 allele of the IL4 gene and IL-4 cytokine hyperproduction is the unfavorable factor for the asthma uncontrolled course. The reduced serum level of IL-10 and A-597 allelic variant of the IL10 gene enhance the control of asthma in children.
About Authors (Correspondence):
Smolnikova M.V. – candidate of biological sciences, leading researcher, e-mail: email@example.com
Smirnova S.V. – doctor of medical sciences, professor, acting director, e-mail: firstname.lastname@example.org
Konopleva O.S. – candidate of medical sciences, senior researcher, e-mail: email@example.com