Cytokines and genes polymorphism in the promoter regions (C-590T IL4 and C-597A IL10) as markers of uncontrolled atopic bronchial asthma in children
Author Affiliations1Research Institute of Medical Problems of the North, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g
2Research Institute of Medical Problems of the North, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g
3Research Institute of Medical Problems of the North, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g
Abstract
The aim. To study an association between the promoter polymorphisms of the IL4 (C-590T) and IL10 (C-597A) genes and serum cytokines level in children with atopic bronchial asthma. Material and methods. The immune status parameters, serum cytokines level and gene polymorphism С-590Т IL4 and С-597А IL10 has been evaluated in seventy four children with asthma. Results and discussion. The occurrence of T-590 allele of the IL4 gene and IL-4 cytokine hyperproduction is the unfavorable factor for the asthma uncontrolled course. The reduced serum level of IL-10 and A-597 allelic variant of the IL10 gene enhance the control of asthma in children.
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References
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About Authors (Correspondence):
Smolnikova M.V. – candidate of biological sciences, leading researcher, e-mail: smarinv@mail.ru
Smirnova S.V. – doctor of medical sciences, professor, acting director, e-mail: svetvita@mail.ru
Konopleva O.S. – candidate of medical sciences, senior researcher, e-mail: olya_tyutina@mail.ru
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