Cytokines and genes polymorphism in the promoter regions (C-590T IL4 and C-597A IL10) as markers of uncontrolled atopic bronchial asthma in children
Author Affiliations1Research Institute of Medical Problems of the North, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g
2Research Institute of Medical Problems of the North, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g
3Research Institute of Medical Problems of the North, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g
Abstract
The aim. To study an association between the promoter polymorphisms of the IL4 (C-590T) and IL10 (C-597A) genes and serum cytokines level in children with atopic bronchial asthma. Material and methods. The immune status parameters, serum cytokines level and gene polymorphism С-590Т IL4 and С-597А IL10 has been evaluated in seventy four children with asthma. Results and discussion. The occurrence of T-590 allele of the IL4 gene and IL-4 cytokine hyperproduction is the unfavorable factor for the asthma uncontrolled course. The reduced serum level of IL-10 and A-597 allelic variant of the IL10 gene enhance the control of asthma in children.
Key words
References
- Genetics of the bronchopulmonary diseases / Ed. V.P. Puzyrev, L.M. Ogorodova. Moscow, 2010. 160 p. (in Russian)
- Geppe N.A. The topicality of the bronchial asthma in children // Pediatriya. 2012. 91 (3). 76–82. (in Russian)
- Global strategy in treatment and prophylaxis of bronchial asthma (amendment of 2007) / Ed. A.G. Chuchalin. Moscow: Atmosphera. 2008. 108 p. (in Russian)
- Konenkov V.I., Smolnikova M.V. Structural bases and functional meaning of allele polymorphism in human cytokine genes and their receptors // Meditsinskaya immunologiya. 2003. 5. (1–2). 11–28. (in Russian)
- Smirnova S.V., Zenkina L.V., Ignatova I.A., Kadricheva S.G. The concentration of IL-2, IL-4, IL-6 and IFNg in the peripheral blood and nasal washes in respiratory atopy and psevdoatopii // Rossiyskiy allergologicheskiy zhurnal. 2005. (1). 30–33. (in Russian)
- Smirnova S.V., Pytsky V.I. Pathogenesis of the veritable allergy and pseudoallergy: educational allowance. Krasnoyarsk; Moscow, 2002. 21 p. (in Russian)
- Smol’nikova M.V., Smirnova S.V., Tyutina O.S., Bychkovskaya S.V. Polymorphism of cytokine genes (IL4, IL10) and features of the immune response depending on the level of control over the course of atopic asthma in children // Rossiyskiy allergologicheskiy zhurnal. 2013. (2). 23–28. (in Russian)
- Bidwell J., Keen L., Gallageher G. et al. Cytokine gene polymorphism in human disease: on-line databases // Genes Immun. 1999. (1). 3–19.
- Cantagrel A., Navaux F., Loubet-Lescoulié P. et al. Interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: relationship to occurrence and severity of rheumatoid arthritis // Arthritis Rheum. 1999. 42. 1093–1100.
- Dmitrieva-Zdorova E.V., Voronko O.E., Latysheva E.A. et al. Analysis of polymorphisms in T(H)2-associated genes in Russian patients with atopic bronchial asthma // J. Investig. Allergol. Clin. Immunol. 2012. 22. (2). 126–132.
- Freidin M.B., Puzyrev V.P., Kobyakova O.S., Ogorodova L.M. Association of polymorphisms in the human IL4 and IL5 genes with atopic bronchial asthma and severity of the disease // Comp. Func. Genomics. 2003. 4. (3). 346–350.
- Padyukov L., Smolnikova M., Klareskog L. et al. Рolymorphism in promoter region of il10 gene is associated with rheumatoid arthritis in women // J. Rheum. 2004. 31. (3). 422–425.
- Smirnova S., Smolnikova M., Tereshchenko S. Immune response and polymorphism of the cytokine genes (IL4, IL10 and IL2, TNFA) in atopic bronchial asthma in Russian children // Allergy. 2014. 69. 227.
About Authors (Correspondence):
Smolnikova M.V. – candidate of biological sciences, leading researcher, e-mail: smarinv@mail.ru
Smirnova S.V. – doctor of medical sciences, professor, acting director, e-mail: svetvita@mail.ru
Konopleva O.S. – candidate of medical sciences, senior researcher, e-mail: olya_tyutina@mail.ru
Full Text