Interleukin-6 in predicting the course of postoperative period in patients with periprosthetic infection of the hip
Author Affiliations1Scientific Center of Restorative Traumatology and Orthopedics n.a. acad.G.I. Ilizarov of Minzdrav of Russia, 640014 Kurgan, M. Ulyanov str., 6
2Scientific Center of Restorative Traumatology and Orthopedics n.a. acad.G.I. Ilizarov of Minzdrav of Russia, 640014 Kurgan, M. Ulyanov str., 6
3Scientific Center of Restorative Traumatology and Orthopedics n.a. acad. G.A. Ilizarov of Minzdrav of Russia 640014, Kurgan, Mariya Ul’ianova str., 6
4Scientific Center of Restorative Traumatology and Orthopedics n.a. acad. G.A. Ilizarov of Minzdrav of Russia 640014, Kurgan, Mariya Ul’ianova str., 6
Abstract
The IL-6 content has been investigated in patients with the hip periprosthetic infection in the process of surgical treatment. According to the data obtained, it is possible to predict the absence of infection recurrence for six coming months of the postoperative period for the following IL-6 values: ≤ 6 pg/ml before surgery, ≤ 7 pg/ml 7, 21, 30 – 45 days after surgery. When IL-6 values increased as follows: ≥11 pg/ml before surgery, ≥19 pg/ml 3 days, ≥8 pg/ml 21 days, ≥18 pg/ml 30-45 days after surgery, there was high probability of infection complication development.
Key words
References
- Petrova N.V. Diagnosis of implant-associated infections in orthopaedics in terms of evidence-based medicine. Hirurgiya pozvonochnika 2012. (1). 74–83. (In Russian)
- Berbari E., Mabry T., Tsaras G., Spangehl M. et al. Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2010. 92. (11). S2102–S2109.
- Buttaro M.A., Tanoira I., Comba F., Piccaluga F. Combining C-reactive protein and interleukin-6 may be useful to detect periprosthetic hip infection. Clin. Orthop. Relat. Res. 2010. 468. (12). 3263–3267.
- Darwiche H., Barsoum W.K., Klika A. et al. Retrospective analysis of infection rate after early reoperation in total hip arthroplasty. Clin. Orthop. Relat. Res. 2010. 468. (9). 2392–2396.
- Di Cesare P.E., Chang E., Preston C.F. et al. Serum Interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J. Bone Joint Surg. Am. 2005. 87. 1921–1927.
- Drago L., Vassena C., Dozio E. et al. Procalcitonin, C-reactive protein, interleukin-6, and soluble intercellular adhesion molecule-1 as markers of postoperative orthopaedic joint prosthesis infections. Int. J. Immunopathol. Pharmacol. 2011. 24. (2). 433–440.
- Elgeidi A., Elganainy A.E., Abou Elkhier N., Rakha S. Interleukin-6 and other inflammatory markers in diagnosis of periprosthetic joint infection. Int. Orthop. 2014. 38. (12). 2591–2595.
- Finn A., Angeby Möller K., Gustafsson C., Abdelmoaty S. et al. Influence of model and matrix on cytokine profile in rat and human Rheumatology (Oxford) // 2014. 53. (12). 2297–2305.
- Hoell S., Borgers L., Gosheger G. et al. Interleukin-6 in two-stage revision arthroplasty: what is the threshold value to exclude persistent infection before re-implanatation?. Bone Joint J. 2015. 97-B. (1). 71–75.
- Jacovides C.L., Parvizi J., Adeli B., Jung K.A. Molecular markers for diagnosis of periprosthetic joint infection. J Arthroplasty. 2011. 26. (6). 99–103.
- Papanicolaou D.A., Wilder R.L., Manolagas S.C., Chrousos G.P. The pathophysiologic roles of interleukin-6 in human disease. Ann. Intern. Med. 1998. 128. (2). 127–137.
- Randau T.M., Friedrich M.J., Wimmer M.D. et al. Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening. PLoS One. 2014. 9. (2). ID 89045.
- Shah K., Mohammed A., Patil S. et al. Circulating cytokines after hip and knee arthroplasty: a preliminary study. Clin. Orthop. Relat. Res. 2009. 467. (4). 946–951.
- Springer B.D., Scuderi G.R. Evaluation and management of the infected total knee arthroplasty. Instr. Course Lect. 2013. 62. 349–361.
- Wirtz D.C., Heller K.D., Miltner O. et al. Interleukin-6: a potential inflammatory marker after total joint replacement. Int. Orthop. 2000. 24. 194–196.
- Yoshitake F., Itoh S., Narita H. et al. Interleukin-6 directly inhibits osteoclast differentiation by suppressing receptor activator of NF-kappaB signaling pathways. J. Biol. Chem. 2008. 283. (17). 11535–11540.
About Authors (Correspondence):
Chepeleva M.V. – candidate of medical sciences, senior researcher of clinical laboratory of microbiology and immunology, e-mail: Vladi_2000@hotbox.ru
Klyushin N.M. – doctor of medical sciences, head of the laboratory of pyogenic osteology, e-mail: elenka@mail.ru
Ermakov A.M. – orthopaedic surgeon of bone infection department 1, e-mail: elenka@mail.ru
Ababkov Yu.V. – orthopaedic surgeon, head of bone infection department 1, e-mail: elenka@mail.ru
Full Text
