The Siberian Scientific Medical Journal
№ 6 / 2015 / 52-55

Studying of energy balance regulators – leptin and CXCL8 chemokin levels under condition of premature birth threatening and at preeclampsia

Author Affiliations


The levels of leptin and CXCL8 chemokine in case of premature birth have been investigated. 67 pregnant women under condition of premature birth threatening and at preeclampsia have been examined. It has been revealed that the leptin level tended to the elevation and CXCL8 content was significantly increased in case of threatening premature birth. Thereat, the values of both indexes were significantly higher than control levels at preeclampsia. The leptin low values were revealed in 10 % of premature birth threatening cases that testified to the increase in uterus contractile activity. The increased CXCL8 level activates neutrophils that works towards the premature birth induction. Both of these indicators can be recommended in a complex with other methods for pregnancy course forecasting in case of premature birth threatening.

Key words

CXCL8, premature birth, leptin, sterile inflammation, chemokines, cytokines
About Authors (Correspondence):

Shcherbakov V.I. – doctor of medical sciences, researcher of laboratory of immunology, e-mail:

Pozdnyakov I.M. – doctor of medical sciences, professor of the chair for obstetrics and gynecology, the chief doctor

Shirinskaya A.V. – obstetrician-gynecologist, e-mail:

Volkov M.V. – obstetrician-gynecologist, e-mail:

Full Text

Received: 12/01/2016