The Siberian Scientific Medical Journal
 
 
№ 1 / 2016 / 70-79

Patient-specific 1D model of the human cardiovascular system

Author Affiliations

Abstract

The technique of parameter personalization of 1D hemodynamic model is discussed and validated against physiological data of 1546 examined patients. Different parameter combinations were used, with the quality of prediction of the systolic and diastolic pressures used as the principle validation criterion. It is shown that with an appropriate personalization the model can provide adequate predictions (correlations near 0.9), where the decisive role is played by the total peripheral resistance parameter. Meanwhile parameters of the largest arteries do not play a significant role in the prediction.

Key words

validation, mathematical modeling, 1D arterial tree model, parameters personalization, cardiovascular system, experimental data
References
About Authors (Correspondence):

Kiselev I.N. – junior researcher, e-mail: axec@developmentontheedge.com

Kolpakov F.A. – candidate of biological sciences, director, head of laboratory for bioinformatics

Biberdorf E.A. – candidate of physical mathematical sciences, docent, senior researcher, e-mail: biberdorf@ngs.ru

Baranov V.I. – candidate of biological sciences, senior researcher of laboratory for organism functional reserves, e-mail: v.i.baranov@physiol.ru

Komlyagina T.G. – researcher of laboratory for organism functional reserves, e-mail: KomlyaginaTG@physiol.ru

Suvorova I.Yu. – junior researcher of laboratory for organism functional reserves, e-mail: suvorovaiu@physiol.ru

Melnikov V.N. – doctor of biological sciences, leading researcher of laboratory for organism functional reserves, e-mail: mvn@physiol.ru

Krivishchekov S.G. – candidate of medical sciences, professor, head of laboratory for organism functional reserves, e-mail: krivosch@physiol.ru

Full Text

Received: 22/03/2016
Accepted: 02/01/1970