The Siberian Scientific Medical Journal
 
 
№ 4 / 2016 / 25-31

Epiphysis-immune relationship in mice of CBA and C57BL/6J strains

Author Affiliations

Abstract

Purpose of the study. To identify the features of the relationship between the pineal gland and organs of the immune system in mice CBA and C57BL / 6J with high and low levels of endogenous melatonin. Material and methods. Lymphocyte subsets were determined by flow cytometry, autofluorescence of lipofuscin epiphysis and thymus was recorded by confocal microscopy. Results and discussion. The greater correlations between the parameters of the epiphysis and cellular composition organs of the immune system, as well as between the number of cell subsets in the thymus, spleen and blood were revealed in C57BL / 6J mice as compared to mice CBA. This testifies to the epiphysis greater importance in the pineal endocrine-immune relationships and increased tension in intercellular interactions of the immune system with low endogenous melatonin levels in mice C57BL/6J.

Key words

lymphocyte, spleen, thymus, pineal gland
References
About Authors (Correspondence):

Litvinenko G.I. – doctor of medical sciences, leading researcher of the laboratory for chronophysiology, e-mail: litv_g_i@mail.ru

Gritsyk O.B. – candidate of medical sciences, senior researcher of the laboratory for chronophysiology, e-mail: oks-gricik@yandex.ru

Avrorov P.A. – researcher of the laboratory for chronophysiology, e-mail: pavel.avrorov@gmail.com

Melnikova E.V. – researcher of the laboratory for chronophysiology, e-mail: gennyma@gmail.com

Shurlygina A.V. – doctor of medical sciences, professor, chief researcher of the laboratory for chronophysiology, e-mail: anna_v_s@mail.ru

Trufakin V.A. – academician of RAS, doctor of medical sciences, professor, head of the laboratory
for chronophysiology, e-mail: trufakin@physiol.ru

Received: 31/08/2016