№ 4 / 2016 / 56-60

Antitumor properties of the Curcuma longa l. Rhizomes glycerine extract on the mice melanoma B16 cells growth model

Author: Lyubimov G.Yu.¹, Goldina I.A.², Gaydul K.V.³, Kozlov V.A.⁴

Abstract

The aim of this study was to determine the antitumor activity of the turmeric rhizomes modified powder of glycerol extract on mouse melanoma B16 model. Material and methods. The study was performed on 30 female mice (CBA x C57BL / 6) F1. Beyond 7 days of the inoculation of melanoma cells, and within 21 days of the experiment the turmeric extract was added into the food of the experimental group animals. Modification of turmeric powder was carried out by the mechanical grinding with immobilization on polymeric carrier – dextrane 10,0 kD up to size of 20-100 nm. Results. The weight reduction of tumor foci in the muscles under the turmeric extract influence was identified, that indicates its anti-tumor properties.

Key words

curcuma, nanoparticles, melanoma B16, antitumor properties, mechanical modification, extract, glycerin

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About Authors (Correspondence):

Lyubimov G.Yu. – candidate of medical sciences, researcher of the immunopoiesis regulation laboratory, e-mail: glubimov@rambler.ru

Goldina I.A. – researcher of the immunopoiesis regulation laboratory, e-mail: igoldina@mail.ru

Gaydul K.V. – doctor of medical sciences, professor, head of the immunopoiesis regulation laboratory, e-mail: kgaidul@mail.ru

Kozlov V.A. – academician of RAS, doctor of medical sciences, professor, scientific adviser, e-mail: vkoz@yandex.ru

Received: 31/08/2016