№ 5 / 2016 / 35-42

Additional molecular-genetic predictors of non-hodgkin malignant lymphoma

Author: Pospelova T.I.¹, Filipenko M.L.², Beresina O.V.³, Voropaeva E.N.⁴, Marinkin I.O.⁵

Abstract

The role of single nucleotide substitutions at seven genes in the folate cycle in susceptibility to NHL has been investigated. The association with decreased risk of NHL for the rare alleles of the gene MTHFD1 1258A and 2756G gene MTR (OR = 0.578, CI [0.415–0.805], p < 0.001; OR = 0,902; CI [0.821–0.991], p = 0.03) has been revealed. The homozygous T/T-genotype SHMT1 increases the risk of aggressive lymphoma in 2.2 times (p < 0.02). These single nucleotide polymorphisms may be considered as potential molecular-genetic predictors of predisposition to NHL.

Key words

non-Hodgkin's lymphoma, polymorphism, folate cycle, aggressive lymphoma

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Received: 08/11/2016