Prevalence of myelofibrosis in chronic myeloid leukemia, multiple myeloma and chronic lymphocytic leukemia in different phases of diseases
Author Affiliations1Institute of Molecular Pathology and Pathomorphology, 630117, Novosibirsk, Timakov str., 2; State Novosibirsk Regional Clinical Hospital, 630087, Novosibirsk , Nemirovicha-Danchenko str., 130
2Institute of Molecular Pathology and Pathomorphology, 630117, Novosibirsk, Timakov str., 2; State Novosibirsk Regional Clinical Hospital, 630087, Novosibirsk , Nemirovicha-Danchenko str., 130
Abstract
A pathomorphological study of bone marrow trephine biopsy of 129 patients with CML, CLL and MM in dynamics of chemotherapy was performed, the average age of the patients was 59.4 ± 2.3 years. The prevalence of initial and expressed myelofibrosis in the patients with chronic myeloid leukemia is higher than that in the patients with the initial presentation and progression of multiple myeloma and chronic lymphocytic leukemia. A direct correlation between the duration of disease and the prevalence of initial and expressed myelofibrosis in the patients with chronic myeloid leukemia, multiple myeloma and chronic lymphocytic leukemia was found. Response to chemotherapy in patients with chronic myeloid leukemia and chronic lymphocytic leukemia is characterized by a decrease in the prevalence of both initial and expressed myelofibrosis.
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About Authors (Correspondence):
Domnikova N.P. – doctor of medical sciences, professor, head of the laboratory of molecular and immunomorphological bases of hematology, head of hematology department with block aseptic chambers, e-mail: pathol@inbox.ru
Dolgikh T.Yu. – candidate of medical sciences, senior researcher of the laboratory of molecular and immunomorphological bases of hematology, hematologist of hematology department with block aseptic chambers, e-mail: pathol@inbox.ru
