Bronchial asthma and gastroesophageal reflux disease: endless dialogue
Author Affiliations1Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasniy av., 52
2Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasniy av., 52
3Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
4Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasniy av., 52
5Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasniy av., 52
Abstract
The prevalence of gastroesophageal reflux disease (GERD) is higher in patients with bronchial asthma (BA) than in the general population. GERD can cause coughing and aggravate asthma. The mechanism of reflux associated chronic cough includes micro and macro aspiration, larynx damage and reflexes mediated by the vagus nerve. Physiological changes under asthma exacerbations as well as the effect of some medicines used for asthma treatment may worsen GERD. The symptoms of GERD and asthma have been analyzed; functional tests have been carried out. The typical clinical symptoms of GERD combined with asthma have been described. The relationship between respiratory symptoms and severity of GERD has been determined.
Key words
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About Authors (Correspondence):
Tikhomirova E.G. – candidate of medical sciences, associate professor of internal diseases chair, e-mail: egtikhomirova@gmail.com
Kudelya L.M. – doctor of medical sciences, professor, honored physician of the RF, head of pulmonological department, professor of the internal diseases chair, chief pulmonologist of the Novosibirsk region
Sidorova L.D. – doctor of medical sciences, professor, academician of RAS, honored scientist, professor of the internal diseases chair
Mozhina L.N. – candidate of medical sciences, associate professor of the internal diseases chair
Manzhileeva T.V. – candidate of medical sciences, assistant of internal diseases chair
