№ 6 / 2016 / 12-17

Assessment of haemostatic properties of new topical antibiotics-containing preparation based on oxidized cellulose in the experiment

Author: Tarkova A.R.¹, Morozov S.V.², Tkacheva N.I.³, Rodionov V.I.⁴, Grigor’ev I.A.⁵, Chernyavskiy A.M.⁶

Abstract

Hemostatic properties of the new antibiotic-containing agent based on oxidized cellulose were evaluated on models WAG rats. It has been revealed that the polyfunctional hemostatic agent with antibacterial effect has hemostatic properties, as well as its analogue – hemostatic agent without antibiotic. The median of bleeding time was 39 (28.5; 50) and 36 (26; 39) seconds, respectively (p = 0.2).

Key words

nosocomial infection, hemostatic materials based on oxidized cellulose, diffuse bleeding

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About Authors (Correspondence):

Tarkova A.R. – postgraduate student of the unit for aorta, coronary and peripheral artery surgery, e-mail: artarkova@mail.ru

Morozov S.V. – candidate of chemical sciences, head of the laboratory of ecological research and chromatography, e-mail: morozov@nioch.nsc.ru

Tkacheva N.I. – candidate of chemical sciences, senior researcher of the laboratory of ecological research and chromatography, e-mail: yaroshen@nioch.nsc.ru

Rodionov V.I. – candidate of chemical sciences, head of unit, e-mail: virod@nioch.nsc.ru

Grigor’ev I.A. – doctor of chemical sciences, professor, head of the laboratory of nitrogen compounds, e-mail: grig@nioch.nsc.ru

Chernyavskiy A.M. – doctor of medical sciences, professor, head of the unit for aorta, coronary and peripheral artery surgery, e-mail: amchern@mail.ru

Received: 27/12/2016