The Siberian Scientific Medical Journal
 
 
№ 6 / 2016 / 60-64

Formation of neutrophilic extracellular traps in patients with osteoarthrosis and the hip replacement outcome

Author Affiliations

Abstract

Using the clinical material the authors carried out the comparative analysis of neutrophilocyte ability to form extracellular traps in patients with Stage III primary osteoarthrosis (OA) of the hip, with aseptic instability, with periprosthetic infection, as well as in patients with uncomplicated postoperative course in the long-term periods after primary replacement of the hip. Peripheral blood smears stained by Romanovsky–Gimza used for neutrophil extracellular trap (NET) counting. According to the obtained data, neutrophil phagocytes in patients with periprosthetic infection, as well as in those with implant aseptic instability were characterized by the greatest ability to form NET thereby indicating that not only bacterial agents, but non-bacterial factors as well (cartilage degradation products in case of OA and debris in case of implant aseptic instability) can induce external phagocytosis in patients with post-replacement complications.

Key words

implant aseptic instability, neutrophil extracellular traps, osteoarthrosis, periprosthetic infection
References
About Authors (Correspondence):

Kuznetsova E.I. –  junior researcher, e-mail: citoz@mail.ru

Chepeleva M.V. – candidate of medical sciences, senior researcher, e-mail: Vladi_2000@hotbox.ru

Chegurov O.K.doctor of medical sciences, head of department of traumatology and orthopedics, head of the laboratory of reconstructive arthroplasty and arthroscopy

Klyushin N.M. doctor of medical sciences, head of the laboratory of pyogenic osteology and limb defect filling, traumatologist-orthopedist, e-mail: elenka_kgn@mail.ru

Sazonova N.V. – doctor of medical sciences, head of consultative diagnostic department, e-mail: nv.sazonova@yandex.ru

Kaminskiy A.V.candidate of medical sciences, head of department of traumatology and orthopedics, senior researcher, traumatologist-orthopedist

Ermakov A.M.traumatologist

Ababkov Yu.V. head of purulent department of traumatology and orthopedics, traumatologist-orthopedist

Kamshilov B.V.candidate of medical sciences, head of department of traumatology and orthopedics, traumatologist-orthopedist

Received: 27/12/2016